Endothelial dysfunction and angiogenesis impairment in the ageing vasculature

医学 血管生成 内皮功能障碍 老化 内皮 微循环 病态的 扩张器 氧化应激 机制(生物学) 内科学 病理 生物信息学 心脏病学 生物 哲学 认识论
作者
Zoltán Ungvári,Stefano Tarantini,Tamás Kiss,Jonathan D. Wren,Cory B. Giles,Courtney T. Griffin,Walter L. Murfee,Pál Pacher,Anna Csiszár
出处
期刊:Nature Reviews Cardiology [Nature Portfolio]
卷期号:15 (9): 555-565 被引量:349
标识
DOI:10.1038/s41569-018-0030-z
摘要

Ageing is the main risk factor for the development of cardiovascular diseases. A central mechanism by which ageing promotes vascular pathologies is compromising endothelial health. The age-related attenuation of endothelium-dependent dilator responses (endothelial dysfunction) associated with impairment of angiogenic processes and the subsequent pathological remodelling of the microcirculation contribute to compromised tissue perfusion and exacerbate functional decline in older individuals. This Review focuses on cellular, molecular, and functional changes that occur in the endothelium during ageing. We explore the links between oxidative and nitrative stress and the conserved molecular pathways affecting endothelial dysfunction and impaired angiogenesis during ageing. We also speculate on how these pathological processes could be therapeutically targeted. An improved understanding of endothelial biology in older patients is crucial for all cardiologists because maintenance of a competently functioning endothelium is critical for adequate tissue perfusion and long-term cardiac health. Cellular, molecular, and functional changes occur in the endothelium during ageing. Ungvari and colleagues explore the links between oxidative and nitrative stress and the conserved molecular pathways affecting endothelial dysfunction and impaired angiogenesis during ageing, and also speculate on how these pathological processes might be therapeutically targeted.
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