干细胞
再生医学
生物
干细胞疗法
旁分泌信号
再生(生物学)
血管生成
细胞生物学
细胞疗法
神经科学
癌症研究
生物化学
受体
作者
Nurul Hafizah Mohd Nor,Nur Izzati Mansor,Mohd Izhar Ariff Mohd Kashim,Mohd Helmy Mokhtar,Farah Ayuni Mohd Hatta
标识
DOI:10.3390/ijms241411763
摘要
Stem cells derived from human exfoliated deciduous teeth (SHED) have emerged as an alternative stem cell source for cell therapy and regenerative medicine because they are readily available, pose fewer ethical concerns, and have low immunogenicity and tumourigenicity. SHED offer a number of advantages over other dental stem cells, including a high proliferation rate with the potential to differentiate into multiple developmental lineages. The therapeutic effects of SHED are mediated by multiple mechanisms, including immunomodulation, angiogenesis, neurogenesis, osteogenesis, and adipogenesis. In recent years, there is ample evidence that the mechanism of action of SHED is mainly due to its paracrine action, releasing a wide range of soluble factors such as cytokines, chemokines, and trophic factors (also known as ‘secretome’) into the local tissue microenvironment to promote tissue survival and recovery. This review provides an overview of the secretome derived from SHED and highlights the bioactive molecules involved in tissue regeneration and their potential applications in regenerative medicine.
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