超氧化物歧化酶
胆固醇
化学
载脂蛋白B
甘油三酯
一氧化氮合酶
一氧化氮
药理学
内分泌学
内科学
血脂异常
抗氧化剂
生物化学
生物
医学
肥胖
作者
Yuwen Shi,Mengcheng Jiang,Yuhang Zhang,Yuan-Yuan Diao,Na Li,Weipeng Liu,Zhidong Qiu,Ye Qiu,Ailing Jia
出处
期刊:Molecules
[MDPI AG]
日期:2023-06-29
卷期号:28 (13): 5088-5088
被引量:2
标识
DOI:10.3390/molecules28135088
摘要
Atherosclerosis (AS) is a serious threat to human health and the main pathological basis of cardiovascular disease. Hyperoside (Hyp), a flavonoid found mainly in traditional Chinese herbs, can exert antitumor, anti-inflammatory, antioxidant, and cardiovascular-protective effects. Herein, we prepared hybrid nanomicelles (HFT) comprising Hyp loaded into pluronic F-127 and polyethylene glycol 1000 vitamin E succinate and assessed their effects on AS. To establish an AS model, apolipoprotein-E-deficient (ApoE-/-) mice were fed a high-fat diet. We then analyzed the effects of HFT on AS-induced changes in aortic tissues and metabolic markers, simultaneously assessing changes in gut flora community structure. In mice with AS, HFT significantly reduced the aortic plaque area; decreased levels of total cholesterol, triglyceride, low-density lipoprotein cholesterol, inflammatory factors, and inducible nitric oxide synthase (NOS); increased high-density lipoprotein cholesterol, endothelial NOS, superoxide dismutase, catalase, and glutathione levels; and promoted the proliferation of beneficial gut bacteria. HFT could regulate intestinal flora structure and lipid metabolism and inhibit inflammatory responses. These beneficial effects may be mediated by inhibiting nuclear factor kappa B signal activation, reducing inflammatory factor expression and improving gut microflora structure and dyslipidemia. The present study provides an empirical basis for the development and clinical application of new dosage forms of Hyp.
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