水泥
免疫系统
兴奋剂
生物活性玻璃
骨水泥
材料科学
医学
复合材料
免疫学
光电子学
作者
Qiyuan Dai,Zetao Wang,Cong Liu,Xiaofeng Chen,Xiaodong Cao
出处
期刊:Biomaterials advances
日期:2024-04-18
卷期号:160: 213864-213864
被引量:2
标识
DOI:10.1016/j.bioadv.2024.213864
摘要
Although calcium phosphate has been extensively utilized in orthopedic applications such as spine, limbs, dentistry, and maxillofacial surgery, the lack of osteoinductive properties often hinders its effectiveness in treating bone defects resulting from pathological micro-environment such as tumor surgery, osteoporosis, osteomyelitis, and diabetic. Therefore, a novel bone cement based on magnesium-doped bioactive glass was developed in this study. The moderate release of magnesium ions improved the mechanical properties by controlling the crystal size of hydroxyapatite. Through detailed discussion of element content and heat treatment temperature, it was found that 2Mg-BG-800 was suitable for the construction of bone cement. 2Mg-BG-BC exhibited favorable initial (15 min) and final (30 min) setting time, compressive strength (29.45 MPa), compressive modulus (1851.49 MPa), injectability, and shape-adaptability. Furthermore, Mg-BG-BC demonstrated the ability to enhance the osteogenic differentiation of BMSCs, and induce macrophage polarization towards the M2 phenotype, suggesting its potential for osteoporotic fracture regeneration.
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