Distinct Plasma Extracellular Vesicle Transcriptomes in Acute Decompensated Heart Failure Subtypes: A Liquid Biopsy Approach

HomeCirculationVol. 149, No. 14Distinct Plasma Extracellular Vesicle Transcriptomes in Acute Decompensated Heart Failure Subtypes: A Liquid Biopsy Approach No AccessLetterRequest AccessFull TextAboutView Full TextView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toNo AccessLetterRequest AccessFull TextDistinct Plasma Extracellular Vesicle Transcriptomes in Acute Decompensated Heart Failure Subtypes: A Liquid Biopsy Approach Priyanka Gokulnath, Michail Spanos, H. Immo Lehmann, Quanhu Sheng, Rodosthenis Rodosthenous, Mark Chaffin, Dimitrios Varrias, Emeli Chatterjee, Elizabeth Hutchins, Guoping Li, George Daaboul, Farhan Rana, Ashley Mingyi Wang, Kendall Van Keuren-Jensen, Patrick T. Ellinor, Ravi Shah and Saumya Das Priyanka GokulnathPriyanka Gokulnath https://orcid.org/0000-0003-2813-330X Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA (P.G., M.S., H.I.L., D.V., E.C., G.L., F.R., A.M.W., P.T.E., S.D.). , Michail SpanosMichail Spanos https://orcid.org/0000-0003-1205-4201 Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA (P.G., M.S., H.I.L., D.V., E.C., G.L., F.R., A.M.W., P.T.E., S.D.). , H. Immo LehmannH. Immo Lehmann https://orcid.org/0000-0003-4379-283X Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA (P.G., M.S., H.I.L., D.V., E.C., G.L., F.R., A.M.W., P.T.E., S.D.). , Quanhu ShengQuanhu Sheng https://orcid.org/0000-0001-8951-9295 Department of Biostatistics (Q.S.), Vanderbilt University Medical Center, Nashville, TN. , Rodosthenis RodosthenousRodosthenis Rodosthenous Institute for Molecular Medicine Finland (FIMM), HiLIFE, University of Helsinki, Finland (R.R.). , Mark ChaffinMark Chaffin https://orcid.org/0000-0002-1234-5562 Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA (M.C., P.T.E.). , Dimitrios VarriasDimitrios Varrias https://orcid.org/0000-0001-9778-1728 Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA (P.G., M.S., H.I.L., D.V., E.C., G.L., F.R., A.M.W., P.T.E., S.D.). , Emeli ChatterjeeEmeli Chatterjee Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA (P.G., M.S., H.I.L., D.V., E.C., G.L., F.R., A.M.W., P.T.E., S.D.). , Elizabeth HutchinsElizabeth Hutchins https://orcid.org/0000-0003-2543-0798 Division of Neurogenomics, Translational Genomics Research Institute, Phoenix, AZ (E.H., K.V.K.-J.). , Guoping LiGuoping Li https://orcid.org/0000-0003-3874-0744 Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA (P.G., M.S., H.I.L., D.V., E.C., G.L., F.R., A.M.W., P.T.E., S.D.). , George DaaboulGeorge Daaboul NanoView Biosciences, Boston, MA (G.D.). , Farhan RanaFarhan Rana Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA (P.G., M.S., H.I.L., D.V., E.C., G.L., F.R., A.M.W., P.T.E., S.D.). , Ashley Mingyi WangAshley Mingyi Wang Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA (P.G., M.S., H.I.L., D.V., E.C., G.L., F.R., A.M.W., P.T.E., S.D.). , Kendall Van Keuren-JensenKendall Van Keuren-Jensen Division of Neurogenomics, Translational Genomics Research Institute, Phoenix, AZ (E.H., K.V.K.-J.). , Patrick T. EllinorPatrick T. Ellinor https://orcid.org/0000-0002-2067-0533 Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA (P.G., M.S., H.I.L., D.V., E.C., G.L., F.R., A.M.W., P.T.E., S.D.). Cardiovascular Disease Initiative, The Broad Institute of MIT and Harvard, Cambridge, MA (M.C., P.T.E.). , Ravi ShahRavi Shah https://orcid.org/0000-0002-4471-7156 Vanderbilt Translational and Clinical Research Center (R.S.), Vanderbilt University Medical Center, Nashville, TN. and Saumya DasSaumya Das Correspondence to: Saumya Das, MD, PhD, Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114. Email E-mail Address: [email protected] https://orcid.org/0000-0002-4521-4606 Cardiovascular Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA (P.G., M.S., H.I.L., D.V., E.C., G.L., F.R., A.M.W., P.T.E., S.D.). Originally published1 Apr 2024https://doi.org/10.1161/CIRCULATIONAHA.123.065513Circulation. 2024;149:1147–1149Footnotes*P. Gokulnath, M. Spanos, and H.I. Lehmann contributed equally.†R. Shah and S. Das contributed equally.For Sources of Funding and Disclosures, see page 1149.Circulation is available at www.ahajournals.org/journal/circCorrespondence to: Saumya Das, MD, PhD, Cardiovascular Research Center, Massachusetts General Hospital, 185 Cambridge St, Boston, MA 02114. Email sdas@mgh.harvard.eduREFERENCES1. Hahn VS, Knutsdottir H, Luo X, Bedi K, Margulies KB, Haldar SM, Stolina M, Yin J, Khakoo AY, Vaishnav J, et al. Myocardial gene expression signatures in human heart failure with preserved ejection fraction.Circulation. 2021; 143:120–134. doi: 10.1161/CIRCULATIONAHA.120.050498LinkGoogle Scholar2. Rodosthenous RS, Hutchins E, Reiman R, Yeri AS, Srinivasan S, Whitsett TG, Ghiran I, Silverman MG, Laurent LC, Van Keuren-Jensen K, et al. Profiling extracellular long RNA transcriptome in human plasma and extracellular vesicles for biomarker discovery.iScience. 2020; 23:101182. doi: 10.1016/j.isci.2020.101182CrossrefMedlineGoogle Scholar3. Chaffin M, Papangeli I, Simonson B, Akkad A-D, Hill MC, Arduini A, Fleming SJ, Melanson M, Hayat S, Kost-Alimova M, et al. Single-nucleus profiling of human dilated and hypertrophic cardiomyopathy.Nature. 2022; 608:174–180. doi: 10.1038/s41586-022-04817-8CrossrefMedlineGoogle Scholar4. Srinivasan S, Yeri A, Cheah PS, Chung A, Danielson K, De Hoff P, Filant J, Laurent CD, Laurent LD, Magee R, et al. Small RNA sequencing across diverse biofluids identifies optimal methods for exRNA isolation.Cell. 2019; 177:446–462.e16. doi: 10.1016/j.cell.2019.03.024CrossrefMedlineGoogle Scholar5. Kumarswamy R, Bauters C, Volkmann I, Maury F, Fetisch J, Holzmann A, Lemesle G, De Groote P, Pinet F, Thum T. Circulating long noncoding RNA, LIPCAR, predicts survival in patients with heart failure.Circ Res. 2014; 114:1569–1575. doi: 10.1161/CIRCRESAHA.114.303915LinkGoogle Scholar eLetters(0)eLetters should relate to an article recently published in the journal and are not a forum for providing unpublished data. Comments are reviewed for appropriate use of tone and language. Comments are not peer-reviewed. Acceptable comments are posted to the journal website only. Comments are not published in an issue and are not indexed in PubMed. Comments should be no longer than 500 words and will only be posted online. References are limited to 10. 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