医学
心房颤动
心脏病学
内科学
心脏淀粉样变性
淀粉样变性
转甲状腺素
心脏复律
导管消融
血栓
作者
George Bazoukis,Athanasios Saplaouras,Panagiotis Efthymiou,Andronicos Yiannikourides,T Liu,Dimitrios Sfairopoulos,Panagiotis Korantzopoulos,Dimitrios Varrias,Κonstantinos P. Letsas,Costas Thomopoulos,Gary Tse,Stavros Stavrakis
标识
DOI:10.1016/j.jjcc.2024.03.008
摘要
Cardiac amyloidosis (CA) is related to the aggregation of insoluble fibrous deposits of misfolded proteins within the myocardium. Transthyretin amyloidosis (ATTR) and immunoglobulin light-chain amyloidosis are the main forms of CA. Atrial fibrillation (AF) is a common arrhythmia in CA patients, especially in those with ATTR amyloidosis. Increased atrial preload and afterload, atrial enlargement, enhanced atrial wall stress, and autonomic dysfunction are the main mechanisms of AF in CA patients. CA is associated with the formation of endocardial thrombi and systemic embolism. The promoters of thrombogenesis include endomyocardial damage, blood stasis, and hypercoagulability. The prevalence of thrombi in patients with AF remains elevated despite long-term anticoagulation. Consequently, transesophageal ultrasound examinations before cardioversion should be performed to exclude endocardiac thrombi despite anticoagulation. Furthermore, the CHA
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