次氯酸
化学
荧光
次氯酸盐
菲咯啉
斯托克斯位移
分析物
检出限
光化学
选择性
活性氧
无机化学
生物化学
催化作用
色谱法
物理
量子力学
作者
Shuqing Tu,Meixia Tan,Ye Guo,Xinyao Wu,Lipeng Li,Wei Li,Wuyuan Pan,Ke Fang
标识
DOI:10.1016/j.tetlet.2023.154373
摘要
A small-molecule reactive oxygen species (ROS) called hypochlorous acid or hypochlorite (HClO/ClO−) plays important roles in both healthy physiological functions and the development of numerous illnesses. On the basis of the imidazo-1,10-phenanthroline skeleton, we have created a new probe for the detection of ClO−. The novel probe demonstrated high selectivity and sensitivity for the detection of ClO−. While other investigated analytes failed to elicit the fluorescence augmentation, the emission spectra after treatment with ClO− showed a dramatic alteration with an approximately 4-fold increase in fluorescence. The emission spectrum is also blue-shifted with a sizable Stokes shift (from 520 nm to 418 nm). In particular, the probe had a fast response time to ClO− (2 min) and a detection limit of up to 0.011 M. The probe could also capture images of HClO in the living cells. The above extraordinary properties illustrated that the probe was able to determine HClO in the living cells.
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