Functional Connectivity and Microstructural Network Correlates of Interindividual Variability in Distinct Executive Functions of Healthy Older Adults

心理学 扣带回(脑) 功能磁共振成像 部分各向异性 执行职能 工作记忆 神经科学 钩束 意识的神经相关物 默认模式网络 前额叶皮质 角回 认知 认知心理学 磁共振弥散成像 磁共振成像 医学 放射科
作者
Friederike Thams,Shu‐Chen Li,Agnes Flöel,Daria Antonenko
出处
期刊:Neuroscience [Elsevier BV]
卷期号:526: 61-73
标识
DOI:10.1016/j.neuroscience.2023.06.005
摘要

Executive functions, essential for daily life, are known to be impaired in older age. Some executive functions, including working memory updating and value-based decision-making, are specifically sensitive to age-related deterioration. While their neural correlates in young adults are well-described, a comprehensive delineation of the underlying brain substrates in older populations, relevant to identify targets for modulation against cognitive decline, is missing. Here, we assessed letter updating and Markov decision-making task performance to operationalize these trainable functions in 48 older adults. Resting-state functional magnetic resonance imaging was acquired to quantify functional connectivity (FC) in task-relevant frontoparietal and default mode networks. Microstructure in white matter pathways mediating executive functions was assessed with diffusion tensor imaging and quantified by tract-based fractional anisotropy (FA). Superior letter updating performance correlated with higher FC between dorsolateral prefrontal cortex and left frontoparietal and hippocampal areas, while superior Markov decision-making performance correlated with decreased FC between basal ganglia and right angular gyrus. Furthermore, better working memory updating performance was related to higher FA in the cingulum bundle and the superior longitudinal fasciculus. Stepwise linear regression showed that cingulum bundle FA added significant incremental contribution to the variance explained by fronto-angular FC alone. Our findings provide a characterization of distinct functional and structural connectivity correlates associated with performance of specific executive functions. Thereby, this study contributes to the understanding of the neural correlates of updating and decision-making functions in older adults, paving the way for targeted modulation of specific networks by modulatory techniques such as behavioral interventions and non-invasive brain stimulation.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
SYLH应助科研通管家采纳,获得20
1秒前
1秒前
赘婿应助科研通管家采纳,获得10
1秒前
Owen应助科研通管家采纳,获得10
1秒前
田様应助科研通管家采纳,获得30
1秒前
JamesPei应助科研通管家采纳,获得10
1秒前
1秒前
所所应助科研通管家采纳,获得10
1秒前
昏睡的蟠桃应助科研通管家采纳,获得200
1秒前
搜集达人应助科研通管家采纳,获得10
1秒前
ding应助科研通管家采纳,获得10
1秒前
Jasper应助科研通管家采纳,获得10
2秒前
在水一方应助科研通管家采纳,获得10
2秒前
2秒前
Ava应助科研通管家采纳,获得10
2秒前
2秒前
2秒前
2秒前
2秒前
2秒前
2秒前
3秒前
3秒前
如云发布了新的文献求助10
4秒前
angela给angela的求助进行了留言
4秒前
4秒前
XZZH完成签到,获得积分10
5秒前
5秒前
独特乘云发布了新的文献求助10
6秒前
WELXCNK发布了新的文献求助10
6秒前
setuin发布了新的文献求助10
7秒前
烟花应助aixue采纳,获得10
8秒前
CC完成签到,获得积分10
8秒前
tyh完成签到,获得积分10
8秒前
完美世界应助Huang采纳,获得10
9秒前
大李完成签到,获得积分10
9秒前
10秒前
10秒前
11秒前
乐乐乐乐乐乐应助大橙子采纳,获得10
11秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038657
求助须知:如何正确求助?哪些是违规求助? 3576306
关于积分的说明 11375198
捐赠科研通 3306108
什么是DOI,文献DOI怎么找? 1819379
邀请新用户注册赠送积分活动 892698
科研通“疑难数据库(出版商)”最低求助积分说明 815066