Survival and Prognosis After Carbon-Ion Radiotherapy in Patients With NSCLC

In the recent study by Kubo et al., 1 Kubo N. Suefuji H. Nakajima M. et al. Five-year survival outcomes after carbon-ion radiotherapy for operable stage I non-small cell lung cancer: a Japanese national registry study (J-CROS-LUNG). J Thorac Oncol. 2024; 19: 491-499 Abstract Full Text Full Text PDF Google Scholar the authors provided real-world information regarding the utilization of carbon-ion radiotherapy (CIRT) for treating operable stage I NSCLC. It was stated that CIRT could provide patients with positive 5-year overall survival and local control rates. Moreover, low associated toxicity levels were observed in this study. On the basis of the findings presented in the current study, the potential viability of CIRT as an alternative to surgical and other interventions for patients with NSCLC could be further evaluated. Five-Year Survival Outcomes After Carbon-Ion Radiotherapy for Operable Stage I NSCLC: A Japanese National Registry Study (J-CROS-LUNG)Journal of Thoracic OncologyVol. 19Issue 3PreviewThe standard therapy for stage I NSCLC is surgery, but some operable patients refuse this option and instead undergo radiotherapy. Carbon-ion radiotherapy (CIRT) is a type of radiotherapy. The Japanese prospective nationwide registry study on CIRT began in 2016. Here, we analyzed real-world clinical outcomes of CIRT for operable patients with stage I NSCLC. Full-Text PDF Open AccessResponse to Letter to the EditorJournal of Thoracic OncologyVol. 19Issue 3PreviewWe appreciate the careful evaluations and concerns raised by Li et al.1 Regarding differences in patient characteristics between the histologically confirmed and nonhistologically confirmed groups, the proportion of patients at stage IB was significantly lower in the nonhistologically confirmed group (6% versus 19%, p = 0.041). Overall survival, cause-specific survival, and progression-free survival, as evaluated by a Cox proportional hazards model, did not differ between the two groups (Table 4, Supplementary Tables 1 and 2). Full-Text PDF