430MO Impact of Nada yoga music therapy on anxiety and quality of life in ovarian cancer patients: A randomized controlled trial

Nadayoga is a complementary therapy known for its potential to reduce anxiety. This study aimed to assess the effects of Nadayoga music on anxiety management and Quality of Life (QoL) in ovarian cancer patients undergoing chemotherapy. In this randomized controlled trial, 58 ovarian cancer patients undergoing chemotherapy were recruited. Participants were randomly assigned to either the Nada yoga music group (Group A) or the Nada yoga music with Instruction group (Group B) using a simple randomization procedure. Instructions for Nada yoga music were recorded by the researcher and delivered to both groups through a custom Android application developed for this study. Follow-up assessments were conducted every three weeks, and anxiety levels were measured using the Hamilton Anxiety Rating Scale, while QoL was assessed using the EORTC QLQ-C30 Quality of Life Questionnaire. Baseline data was collected just before the first chemotherapy session, and post-data was collected after 12 weeks. Data from 49 participants were included in the analysis according to the protocol. Both groups were found to be homogenous with respect to age, weight, and clinical parameters. Significant differences were observed in anxiety scores between the two groups (p = 0.026). Furthermore, a notable improvement in global health status was noted in both groups (p = 0.039). However, no significant changes were observed in physical functioning (p = 0.390), role functioning (p = 0.453), emotional functioning (p = 0.192), cognitive functioning (p = 0.190), or social functioning (p = 0.282). Significant differences were observed in fatigue (p = 0.039), nausea/vomiting (p = 0.009), dyspnoea (p = 0.011), and financial difficulties (p = 0.006) between the two groups, favouring intervention arm. In conclusion, the twelve-week Nadayoga music therapy intervention offers a cost-effective approach to reducing anxiety and improving the quality of life for ovarian cancer patients. This study highlights the potential of Nadayoga music therapy as a valuable addition to comprehensive cancer care, emphasizing its positive impact on emotional well-being and symptom management.