医学
免疫抑制
肺移植
肺
机会性感染
重症监护医学
抗菌剂
免疫学
内科学
人类免疫缺陷病毒(HIV)
病毒性疾病
微生物学
生物
标识
DOI:10.1016/j.idc.2023.12.001
摘要
Opportunistic infections are a leading cause of lung transplant recipient morbidity and mortality. Risk factors for infection include continuous exposure of the lung allograft to the external environment, high levels of immunosuppression , impaired mucociliary clearance and decreased cough reflex , and impact of the native lung microbiome in single lung transplant recipients. Infection risk is mitigated through careful pretransplant screening of recipients and donors, implementation of antimicrobial prophylaxis strategies, and routine surveillance posttransplant. This review describes common viral, fungal, and mycobacterial infectious after lung transplant and provides recommendations on prevention and treatment .
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