医学
握力
慢性炎症性脱髓鞘性多发性神经病
多神经根神经病
四分位间距
多灶性运动神经病
手部力量
物理疗法
儿科
外科
格林-巴利综合征
内科学
失配负性
抗体
免疫学
脑电图
精神科
作者
Apoorva Guttikonda,Ghazal Ahmad,Parul Goyal,Yijin Xiang,Laura Johnson,Scott Gillespie,Kimberly T. Carvell,Robert J. Butera,Sumit Verma
摘要
Abstract Introduction/Aims Objective outcome measures in children undergoing treatment for chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) are lacking. The aim of the study was to record serial grip strength and motor nerve conduction studies to assess interval change. Methods This was a retrospective review of 16 children (8 females and 8 males; median age, 9.7 years; interquartile range, 6–13 years) with CIDP followed at a tertiary children's hospital from 2013 to 2021. Subjects were treated with intravenous immunoglobulin (IVIG). Right and left grip strength measurements were obtained at each clinic visit using a handheld dynamometer. Annual right median motor nerve conduction study data were recorded during the study period. Results Mean duration of follow‐up was 2.9 years. Grip strength (right: 0.19 kg/month, p < 0.001; left 0.23 kg/month, p < 0.001) and median F‐wave latencies (−0.23/month, p = 0.015) showed significant improvement over time. Akaike information criterion showed time + IVIG frequency <21 days as best fit for grip strength and distal compound muscle action potential amplitude. Discussion Our study results indicate serial grip strength measurements are a feasible and objective way to assess motor strength improvement in children with CIDP receiving immunotherapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI