T细胞受体
T细胞
嵌合抗原受体
细胞生物学
主要组织相容性复合体
过继性细胞移植
免疫疗法
抗原
免疫学
生物
化学
免疫系统
作者
Nicholas Jeffreys,Joshua M. Brockman,Yunhao Zhai,Donald E. Ingber,David Mooney
出处
期刊:Applied physics reviews
[American Institute of Physics]
日期:2024-01-19
卷期号:11 (1)
被引量:2
摘要
Adoptive T cell immunotherapies, including engineered T cell receptor (eTCR) and chimeric antigen receptor (CAR) T cell immunotherapies, have shown efficacy in treating a subset of hematologic malignancies, exhibit promise in solid tumors, and have many other potential applications, such as in fibrosis, autoimmunity, and regenerative medicine. While immunoengineering has focused on designing biomaterials to present biochemical cues to manipulate T cells ex vivo and in vivo, mechanical cues that regulate their biology have been largely underappreciated. This review highlights the contributions of mechanical force to several receptor–ligand interactions critical to T cell function, with central focus on the TCR–peptide-loaded major histocompatibility complex (pMHC). We then emphasize the role of mechanical forces in (i) allosteric strengthening of the TCR–pMHC interaction in amplifying ligand discrimination during T cell antigen recognition prior to activation and (ii) T cell interactions with the extracellular matrix. We then describe approaches to design eTCRs, CARs, and biomaterials to exploit TCR mechanosensitivity in order to potentiate T cell manufacturing and function in adoptive T cell immunotherapy.
科研通智能强力驱动
Strongly Powered by AbleSci AI