Defining Minimum Treatment Parameters of Ablative Radiation Therapy in Patients With Hepatocellular Carcinoma: An Expert Consensus

医学 离格 肝细胞癌 放射治疗 医学物理学 外照射放疗 肿瘤科 核医学 放射科 近距离放射治疗 内科学
作者
Ted K. Yanagihara,Joel E. Tepper,Andrew M. Moon,Aisling Barry,Meritxell Mollà,Jinsil Seong,Ferrán Torres,Smith Apisarnthanarax,Michael Buckstein,Higinia R. Cárdenes,Daniel T. Chang,Mary Feng,Chandan Guha,Christopher L. Hallemeier,M. Hawkins,Morten Høyer,Hiromitsu Iwata,Salma K. Jabbour,Lisa A. Kachnic,Jordan Kharofa,Tae Hyun Kim,Alexander Kirichenko,Eugene J. Koay,Hirokazu Makishima,Joel Mases,Jeffrey Meyer,Pablo Muñoz-Schuffenegger,Dawn Owen,Hee Chul Park,Jordi Sáez,Nina N. Sanford,Marta Scorsetti,Grace L. Smith,Jennifer Y. Wo,Sang Min Yoon,Theodore S. Lawrence,María Reig,Laura A. Dawson
出处
期刊:Practical radiation oncology [Elsevier BV]
卷期号:14 (2): 134-145 被引量:1
标识
DOI:10.1016/j.prro.2023.08.016
摘要

Purpose

External beam radiation therapy (EBRT) is a highly effective treatment in select patients with hepatocellular carcinoma (HCC). However, the Barcelona Clinic Liver Cancer system does not recommend the use of EBRT in HCC due to a lack of sufficient evidence and intends to perform an individual patient level meta-analysis of ablative EBRT in this population. However, there are many types of EBRT described in the literature with no formal definition of what constitutes "ablative." Thus, we convened a group of international experts to provide consensus on the parameters that define ablative EBRT in HCC.

Methods and Materials

Fundamental parameters related to dose, fractionation, radiobiology, target identification, and delivery technique were identified by a steering committee to generate 7 Key Criteria (KC) that would define ablative EBRT for HCC. Using a modified Delphi (mDelphi) method, experts in the use of EBRT in the treatment of HCC were surveyed. Respondents were given 30 days to respond in round 1 of the mDelphi and 14 days to respond in round 2. A threshold of ≥70% was used to define consensus for answers to each KC.

Results

Of 40 invitations extended, 35 (88%) returned responses. In the first round, 3 of 7 KC reached consensus. In the second round, 100% returned responses and consensus was reached in 3 of the remaining 4 KC. The distribution of answers for one KC, which queried the a/b ratio of HCC, was such that consensus was not achieved. Based on this analysis, ablative EBRT for HCC was defined as a BED10 ≥80 Gy with daily imaging and multiphasic contrast used for target delineation. Treatment breaks (eg, for adaptive EBRT) are allowed, but the total treatment time should be ≤6 weeks. Equivalent dose when treating with protons should use a conversion factor of 1.1, but there is no single conversion factor for carbon ions.

Conclusions

Using a mDelphi method assessing expert opinion, we provide the first consensus definition of ablative EBRT for HCC. Empirical data are required to define the a/b of HCC.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
郭小宝发布了新的文献求助10
1秒前
情怀应助幸福大白采纳,获得10
1秒前
齐天大圣应助幸福大白采纳,获得30
2秒前
孙燕应助幸福大白采纳,获得30
2秒前
英姑应助幸福大白采纳,获得30
2秒前
2秒前
Hashub完成签到,获得积分20
2秒前
4秒前
xueyu发布了新的文献求助10
6秒前
wonder123发布了新的文献求助10
7秒前
科研通AI2S应助张雯思采纳,获得10
8秒前
8秒前
小二郎应助张雯思采纳,获得10
8秒前
情怀应助张雯思采纳,获得10
8秒前
8秒前
科研通AI2S应助张雯思采纳,获得10
8秒前
今后应助张雯思采纳,获得10
8秒前
在水一方应助张雯思采纳,获得10
8秒前
Jasper应助张雯思采纳,获得10
8秒前
41应助张雯思采纳,获得10
8秒前
8秒前
新xin完成签到,获得积分10
9秒前
儒雅南风发布了新的文献求助10
9秒前
xxddw发布了新的文献求助10
9秒前
33发布了新的文献求助30
9秒前
10秒前
10秒前
Rondab应助科研小白采纳,获得10
11秒前
12秒前
wonder123完成签到,获得积分10
12秒前
量子星尘发布了新的文献求助10
14秒前
幸福的乾发布了新的文献求助10
14秒前
xyj6486发布了新的文献求助10
14秒前
15秒前
小晓发布了新的文献求助10
17秒前
Owen应助伏坎采纳,获得10
20秒前
健壮雨兰完成签到,获得积分10
20秒前
LWQ完成签到,获得积分10
21秒前
wanci应助无名采纳,获得10
21秒前
可爱的函函应助海藻采纳,获得10
22秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
‘Unruly’ Children: Historical Fieldnotes and Learning Morality in a Taiwan Village (New Departures in Anthropology) 400
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3989444
求助须知:如何正确求助?哪些是违规求助? 3531531
关于积分的说明 11254250
捐赠科研通 3270191
什么是DOI,文献DOI怎么找? 1804901
邀请新用户注册赠送积分活动 882105
科研通“疑难数据库(出版商)”最低求助积分说明 809174