体育锻炼
医学
疾病
骨骼肌
FOXP3型
免疫学
干扰素
炎症
线粒体
生物
内科学
免疫系统
细胞生物学
作者
P. Kent Langston,Yizhi Sun,Birgitta Lehtinen,Amber L. Mueller,Bruce M. Spiegelman,Christophe Benoist,Diane Mathis
出处
期刊:Science immunology
[American Association for the Advancement of Science (AAAS)]
日期:2023-11-24
卷期号:8 (89)
被引量:13
标识
DOI:10.1126/sciimmunol.adi5377
摘要
Exercise enhances physical performance and reduces the risk of many disorders such as cardiovascular disease, type 2 diabetes, dementia, and cancer. Exercise characteristically incites an inflammatory response, notably in skeletal muscles. Although some effector mechanisms have been identified, regulatory elements activated in response to exercise remain obscure. Here, we have addressed the roles of Foxp3 + CD4 + regulatory T cells (T regs ) in the healthful activities of exercise via immunologic, transcriptomic, histologic, metabolic, and biochemical analyses of acute and chronic exercise models in mice. Exercise rapidly induced expansion of the muscle T reg compartment, thereby guarding against overexuberant production of interferon-γ and consequent metabolic disruptions, particularly mitochondrial aberrancies. The performance-enhancing effects of exercise training were dampened in the absence of T regs . Thus, exercise is a natural T reg booster with therapeutic potential in disease and aging contexts.
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