痤疮
扩增子测序
痤疮丙酸杆菌
皮肤病科
微生物群
医学
金黄色葡萄球菌
优势(遗传学)
葡萄球菌
疾病
生物
16S核糖体RNA
细菌
内科学
生物信息学
基因
遗传学
作者
Lang Sun,Qingqun Wang,Huan Wang,Jing Huang,Zheng Yu
摘要
Abstract Acne is a chronic disease that often persists for years. Skin microbial communities play an essential role in the development of acne. However, limited information is available about the dynamic patterns of skin microbiota in acne. This study aimed to characterize microbial community changes in skin pores and surfaces of acne patients with varying disease time. In this study, a total of 70 skin samples from 22 subjects were collected and sequenced using 16S rRNA amplicon sequencing. Although microbial compositions in skin pores were similar over time, significant differences in microbial structure were observed on the skin surface, with the dominance of Cutibacterium in the first 3 years and replacement by Staphylococcus in 4–6 years. Lactobacillus and Acinetobacter were more abundant in the normal group and continuingly decreased with disease time on the skin surface. Microbial networks further revealed substantial increases in microbial interactions in the 4–6 years group in both skin surfaces and pores. These results demonstrate that the skin microbiota alters with the disease duration and may provide a potential guide in redirecting skin microbiota towards healthy states.
科研通智能强力驱动
Strongly Powered by AbleSci AI