miR-628-5p is a Potential Novel Prognosis Biomarker, Associated with Immune Infiltration in Bladder Urothelial Carcinoma

膀胱癌 小RNA 免疫系统 肿瘤科 癌症研究 医学 渗透(HVAC) 内科学 生物标志物 PI3K/AKT/mTOR通路 膀胱切除术 生物 基因 信号转导 癌症 免疫学 生物化学 物理 热力学
作者
Hong Huang,Qingchun Xu,Yonghai Zhang,Yizhou Zhou,Kaiqun Ma,Yingxun Luo
出处
期刊:Current Pharmaceutical Design [Bentham Science Publishers]
卷期号:29 (31): 2477-2488
标识
DOI:10.2174/0113816128254621231017062923
摘要

Background:: microRNA-628-5p (miR-628-5p) has a significant impact on certain types of cancer. The precise function of miR-628-5p in the context of bladder urothelial carcinoma (BLCA) remains ambiguous. Objective:: We aimed to investigate the role of miR-628-5p in BLCA. Methods:: The samples were collected from The Cancer Genome Atlas (TCGA). Statistics were employed to evaluate the correlation and predictive significance of miR-628-5p. We analyzed the target genes and regulatory network of miR-628-5p and the correlation between miR-628-5p and immune infiltration. The expression of miR-628-5p in BLCA cells was confirmed by quantitative reverse-transcription PCR (qRT-PCR). Results:: miR-628-5p exhibited differential expression across various types of cancer. There was a significant association between high expression of miR-628-5p and primary therapy outcome (p < 0.05). High expression of miR-628-5p was observed to be associated with poorer overall survival (HR: 1.42; 95% CI: 1.06-1.90; p = 0.02), progress free survival (HR: 1.57; 95% CI: 1.17-2.11; p = 0.003), and disease specific survival (HR: 1.83; 95% CI: 1.28-2.62; p = 0.001) in BLCA. miR-628-5p was an independent prognostic factor in BLCA and may be involved in the development of the disease through various pathways, including focal adhesion, ECM-receptor interaction, PI3K-Akt signaling pathway, and MAPK signaling pathway, and among others. miR-628-5p expression was significantly correlated with immune infiltration in BLCA patients. Compared to normal bladder epithelial cells, BLCA cell lines exhibited a significant upregulation of miR-628-5p. Conclusion:: It is possible that miR-628-5p could serve as a hopeful therapeutic target and prognostic biomarker for individuals with BLCA.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
cheersyu完成签到,获得积分10
刚刚
Walden完成签到,获得积分10
刚刚
无奈曼云完成签到,获得积分10
刚刚
HH完成签到,获得积分10
刚刚
微笑发布了新的文献求助10
1秒前
蕉太狼完成签到,获得积分10
1秒前
wp完成签到,获得积分10
2秒前
away完成签到,获得积分10
2秒前
2秒前
maoxinnan发布了新的文献求助10
2秒前
2秒前
丁静完成签到 ,获得积分10
3秒前
眯眯眼的雪莲完成签到 ,获得积分10
3秒前
3秒前
深情安青应助kento采纳,获得10
3秒前
Paris完成签到,获得积分10
3秒前
小乐应助冷傲凝琴采纳,获得50
4秒前
away发布了新的文献求助10
4秒前
谦让的焱完成签到,获得积分10
5秒前
小鱼完成签到,获得积分10
5秒前
缪绯发布了新的文献求助10
6秒前
6秒前
Messi发布了新的文献求助10
7秒前
天天快乐应助不安火车采纳,获得10
7秒前
科研蚂蚁发布了新的文献求助10
8秒前
KK123456完成签到,获得积分10
8秒前
无昵称完成签到 ,获得积分10
8秒前
水木应助謓言采纳,获得10
8秒前
大模型应助QianShenYu采纳,获得10
9秒前
亦安完成签到,获得积分10
9秒前
10秒前
Linden_bd完成签到 ,获得积分10
10秒前
gfbh应助dtcao采纳,获得10
10秒前
乖猫要努力应助dtcao采纳,获得10
10秒前
思源应助tooty采纳,获得10
10秒前
犹豫觅翠完成签到,获得积分10
10秒前
英姑应助无昵称采纳,获得10
10秒前
Zhihu完成签到,获得积分10
11秒前
11秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
Nucleophilic substitution in azasydnone-modified dinitroanisoles 500
不知道标题是什么 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969322
求助须知:如何正确求助?哪些是违规求助? 3514152
关于积分的说明 11172188
捐赠科研通 3249407
什么是DOI,文献DOI怎么找? 1794832
邀请新用户注册赠送积分活动 875437
科研通“疑难数据库(出版商)”最低求助积分说明 804781