头孢西丁
沙门氏菌
微生物学
萘啶酸
肠沙门氏菌
四环素
氨苄西林
生物
血清型
抗生素耐药性
质粒
多重耐药
抗生素
病毒学
基因
细菌
遗传学
金黄色葡萄球菌
作者
Md. Sekendar Ali,Hyun-Ju Song,Bo‐Youn Moon,Sujeong Kim,Hee Young Kang,Dong Chan Moon,Yeon‐Hee Lee,Dong-Hyeon Kwon,Soon‐Seek Yoon,Suk‐Kyung Lim
出处
期刊:Foodborne Pathogens and Disease
[Mary Ann Liebert]
日期:2023-09-12
卷期号:20 (11): 492-501
被引量:3
标识
DOI:10.1089/fpd.2023.0034
摘要
The production of β-lactamase by nontyphoidal Salmonella has become a public health issue throughout the world. In this study, we aimed to investigate the antimicrobial resistance profiles and molecular characteristics of β-lactamase-producing Salmonella enterica serovar Albany isolates. A total of 434 Salmonella Albany were obtained from feces and carcasses of healthy and diseased food-producing animals [cattle (n = 2), pigs (n = 3), chickens (n = 391), and ducks (n = 38)] during 2013-2020. Among the 434 Salmonella Albany isolates, 3.7% showed resistance to cefoxitin, and all the cefoxitin-resistant isolates were obtained from chickens. Moreover, Salmonella Albany isolates demonstrated high resistance to nalidixic acid (99.3%), trimethoprim/sulfamethoxazole (97.9%), ampicillin (86.6%), chloramphenicol (86.6%), and tetracycline (85.7%), as well as higher rates of multidrug resistance were detected in cefoxitin-resistant isolates compared to cefoxitin-susceptible isolates. All cefoxitin-resistant isolates harbored CMY-2-type β-lactamase and belonged to seven different pulsotypes, with type IV-b (43.75%) and IV-a (25%) making up the majority. In addition, genes encoding cefoxitin resistant of all blaCMY-2-harboring Salmonella Albany isolates were horizontally transmitted to a recipient Escherichia coli J53 by conjugation. Furthermore, 93.75% (15/16) of conjugative plasmids harboring blaCMY-2 genes belong to ST12/CC12-IncI1. Genetic characteristics of transmitted blaCMY-2 genes were associated with ISEcp1, which can play an essential role in the effective mobilization and expression of these genes. Salmonella Albany containing blaCMY-2 in chickens can potentially be transferred to humans. Therefore, it is necessary to restrict antibiotic use and conduct continuous monitoring and analysis of resistant bacteria in the poultry industry.
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