生命银行
生物标志物发现
生物沉积
工作流程
背景(考古学)
生物标志物
医学
医学物理学
计算机科学
生物信息学
生物
数据库
古生物学
生物化学
蛋白质组学
基因
作者
Olga Kofanova,Sangita Paul,Achilleas Pexaras,Camille Bellora,Ala Petersons,Margaux Schmitt,Mohamad Baker Berjaoui,Yazan Qaoud,Miran Kenk,Heidi Wagner,Neil Fleshner,Fay Betsou
标识
DOI:10.1089/bio.2022.0190
摘要
Development of novel biomarkers for diagnosis of disease and assessment of treatment efficacy utilizes a wide range of biospecimens for discovery research. The fitness of biospecimens for the purpose of biomarker development depends on the clinical characteristics of the donor and on a number of critical and potentially uncontrolled pre-analytical variables. Pre-analytical factors influence the reliability of the biomarkers to be analyzed and can seriously impact analytic outcomes. Sample quality stratification assays and tools can be utilized by biorepositories to minimize bias resulting from samples' inconsistent quality. In this study, we evaluated the quality of biobanked specimens by comparing analytical outcomes at 1, 5, and 10 years after collection. Our results demonstrate that currently available assays and tools can be used by biobank laboratories to support objective biospecimen qualification. We have established a workflow to monitor the quality of different types of biospecimens and, in this study, present the results of a qualification exercise applied to fluid samples and their derivatives in the context of urological diseases.
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