成纤维细胞生长因子受体
成纤维细胞生长因子
信号转导
细胞生物学
成纤维细胞生长因子受体3
成纤维细胞生长因子23
成纤维细胞生长因子受体1
受体
成纤维细胞
化学
癌症研究
生物
生物化学
医学
内科学
体外
钙
甲状旁腺激素
作者
Shih‐Hsien Liu,Zhousheng Xiao,Jeremy C. Smith,L. Darryl Quarles
标识
DOI:10.1016/j.tips.2023.09.005
摘要
Chen et al. have derived cryogenic electron microscopy (cryo-EM) structures of signaling complexes of the endocrine hormone fibroblast growth factor 23 (FGF23) with fibroblast growth factor receptor (FGFR), α-Klotho, and heparin sulfate. These structures are asymmetric, leading to questions concerning in vivo function, and will facilitate structure-based drug design to modulate FGF23 signaling.
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