The Internet of Things is to connect all the objects to interact with each other to form an interconnected network. The Internet of Things uses information technology to promote the comprehensive upgrade of human life and production services. In a broad sense, the interworking technology covers the physical field and the information field, which can promote the development of the space of things in the direction of systematization, intelligence and networking. The Internet of Things provides a new technical guarantee for laboratory safety management. In this paper, a variety of sensors, a variety of transmission networks and protocols are applied to achieve a laboratory security system based on the Internet of Things, which provides a new idea for laboratory security management and ensures that the laboratory can serve teaching and scientific research to the maximum extent. The core work of this paper is to design the laboratory security system architecture based on the Internet of Things, and realize the laboratory security monitoring and control system.