Sex-Specific Associations between Adiponectin and Leptin Signaling and Pancreatic Cancer Survival

脂联素 脂肪因子 内科学 医学 内分泌学 人口 脂联素受体1 瘦素 置信区间 单核苷酸多态性 小鼠苗条素受体 胰腺癌 肿瘤科 癌症 胰岛素抵抗 基因型 胰岛素 肥胖 生物 遗传学 基因 环境卫生
作者
Ana Babic,Qiaoli Wang,Alice A. Lee,Chen Yuan,Nader Rifai,Juhua Luo,Fred K. Tabung,Aladdin H. Shadyab,Jean Wactawski‐Wende,Nazmus Saquib,Jihye Kim,Peter Kraft,Howard D. Sesso,Julie E. Buring,Edward L. Giovannucci,Jo Ann E. Manson,Meir J. Stampfer,Kimmie Ng,Charles S. Fuchs,Brian M. Wolpin
出处
期刊:Cancer Epidemiology, Biomarkers & Prevention [American Association for Cancer Research]
卷期号:32 (10): 1458-1469
标识
DOI:10.1158/1055-9965.epi-23-0505
摘要

Circulating adiponectin and leptin have been associated with risk of pancreatic cancer. However, the relationship between long-term exposure to these adipokines in the prediagnostic period with patient survival has not been investigated.Adipokine levels were measured in prospectively collected samples from 472 patients with pancreatic cancer. Because of sex-specific differences in adipokine levels, associations were evaluated separately for men and women. In a subset of 415 patients, we genotyped 23 SNPs in adiponectin receptor genes (ADIPOR1 and ADIPOR2) and 30 SNPs in the leptin receptor gene (LEPR).Adiponectin levels were inversely associated with survival in women [HR, 1.71; 95% confidence interval (CI), 1.15-2.54]; comparing top with bottom quartile but not in men (HR, 0.89; 95% CI, 0.46-1.70). The SNPs rs10753929 and rs1418445 in ADIPOR1 were associated with survival in the combined population (per minor allele HR, 0.66; 95% CI, 0.51-0.84, and HR, 1.33; 95% CI, 1.12-1.58, respectively). Among SNPs in LEPR, rs12025906, rs3790431, and rs17127601 were associated with survival in the combined population [HRs, 1.54 (95% CI, 1.25-1.90), 0.72 (95% CI, 0.59-0.88), and 0.70 (95% CI, 0.56-0.89), respectively], whereas rs11585329 was associated with survival in men only (HR, 0.39; 95% CI, 0.23-0.66; Pinteraction = 0.0002).High levels of adiponectin in the prediagnostic period were associated with shorter survival among women, but not among men with pancreatic cancer. Several polymorphisms in ADIPOR1 and LEPR are associated with patient survival.Our findings reveal the association between adipokine signaling and pancreatic cancer survival and demonstrate the importance of examining obesity-associated pathways in relation to pancreatic cancer in a sex-specific manner.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
无语的凡梦完成签到,获得积分10
刚刚
wanci应助二十四桥明月夜采纳,获得10
1秒前
风清扬应助LaTeXer采纳,获得10
1秒前
leo关闭了leo文献求助
2秒前
推土机爱学习完成签到 ,获得积分10
2秒前
李萍萍发布了新的文献求助10
2秒前
2秒前
fdwang完成签到 ,获得积分10
2秒前
清漪完成签到 ,获得积分10
3秒前
深情安青应助海白采纳,获得10
3秒前
晴栀完成签到,获得积分10
3秒前
hetao286完成签到,获得积分10
4秒前
阿三的风光完成签到 ,获得积分10
4秒前
nature完成签到 ,获得积分10
4秒前
量子星尘发布了新的文献求助10
5秒前
科研狗完成签到 ,获得积分10
6秒前
追光者完成签到,获得积分10
6秒前
HJJHJH发布了新的文献求助10
7秒前
Advance.Cheng发布了新的文献求助10
7秒前
传统的大白完成签到,获得积分10
7秒前
复杂的白秋完成签到,获得积分10
8秒前
8秒前
舒适的平蓝完成签到,获得积分10
9秒前
DAI123完成签到,获得积分10
9秒前
9秒前
阳yang发布了新的文献求助10
9秒前
HIH完成签到 ,获得积分10
10秒前
可靠的寒风完成签到,获得积分10
11秒前
Pan完成签到,获得积分10
11秒前
12秒前
12秒前
12秒前
丢丢丢完成签到,获得积分10
12秒前
安静的ky完成签到,获得积分10
12秒前
JamesPei应助mary采纳,获得10
12秒前
木子林夕完成签到,获得积分10
12秒前
勤奋尔丝完成签到 ,获得积分10
13秒前
13秒前
14秒前
haozi完成签到,获得积分10
14秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
Research on Disturbance Rejection Control Algorithm for Aerial Operation Robots 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038426
求助须知:如何正确求助?哪些是违规求助? 3576119
关于积分的说明 11374556
捐赠科研通 3305834
什么是DOI,文献DOI怎么找? 1819339
邀请新用户注册赠送积分活动 892678
科研通“疑难数据库(出版商)”最低求助积分说明 815029