This chapter introduces the therapeutic application of Glycyrrhizae Radix et Rhizoma for the management of coronavirus disease 2019 (COVID-19). Glycyrrhizae Radix et Rhizoma is also known as glycyrrhiza or licorice and is one of the most commonly used medicinal plants in traditional Eastern medicine and Western herbal medicine. The chapter starts by presenting a general description and a brief history of glycyrrhiza. It then explains the pharmaceutical properties of the components found in glycyrrhiza and their medical application. The highlight of this chapter is the experimental and clinical studies of glycyrrhiza for various diseases including COVID-19.