干细胞
干细胞因子
细胞生物学
生物
骨髓
造血
成体干细胞
再生(生物学)
趋化因子
间充质干细胞
癌症研究
免疫学
炎症
内皮干细胞
体外
生物化学
作者
Yingtong Liu,Zheran Liu,Liqiang Hu,Ling He,Lianlian Yang,Zijian Qin,Yuping Xie,Xingchen Peng,Lei Dai
标识
DOI:10.1080/09553002.2023.2188935
摘要
The aim of this review is to discuss previous studies on the function of stem cells in radiation-induced damage, and the factors affecting these processes, in the hope of improving our understanding of the different stem cells and the communication networks surrounding them. This is essential for the development of effective stem cell-based therapies to regenerate or replace normal tissues damaged by radiation.In salivary glands, senescence-associated cytokines and inflammation-associated cells have a greater effect on stem cells. In the intestinal glands, Paneth cells strongly affect stem cell-mediated tissue regeneration after radiation treatment. In the pancreas, β-cells as well as protein C receptor positive (Procr) cells are expected to be key cells in the treatment of diabetes. In the bone marrow, a variety of cytokines such as CXC-chemokine ligand 12 (CXCL12) and stem cell factor (SCF), contribute to the functional recovery of hematopoietic stem cells after irradiation.
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