免疫系统
生物粘附
溃疡性结肠炎
透明质酸
伤口愈合
自愈水凝胶
炎症性肠病
肠粘膜
炎症
纤维蛋白
再生(生物学)
免疫学
材料科学
生物
细胞生物学
医学
纳米技术
病理
内科学
疾病
药物输送
遗传学
高分子化学
作者
Hong Wen,Liqi Li,Xinyue Ge,Fei Yang,Yanan Li,Menghuan Li,Weidong Xiao,Zhong Luo
标识
DOI:10.1002/adfm.202212566
摘要
Abstract Ulcerative colitis (UC) is a common inflammatory bowel disease driven by the dyshomeostasis of intestinal immune system and microbiota, but its treatment options are limited due to impaired epithelial barrier integrity and function. Herein, a multifunctional biomimetic hydrogel is developed as artificial colonic mucosa, which can readily establish a bioadhesive barrier at the ulcer site and restore local immune and microbial homeostasis to exert potent anti‐inflammatory effect. The hydrogel framework is generated through the thrombin‐mediated activation and polymerization of fibrinogen that resembles natural blood coagulation mechanism. During this process, the antibacterial agent Ag + is used for the crosslinking between the generated fibrin units and dopamine/thiol‐modified hyaluronic acid biopolymers via Ag + ‐thiol coordination to convey enhanced bioadhesiveness, while the interconnected porous network is employed to encapsulate basic fibroblast growth factor (bFGF) and alanyl‐glutamine (ALG) for mucosa regeneration. The hydrogel stably adheres to the ulcer site to protect and repair the damaged epithelium and establishes an anti‐inflammatory microenvironment by inducing locoregional M1‐to‐M2 macrophage repolarization while eliminating harmful gut flora, which can act in a cooperative manner to substantially alleviate UC symptoms. The biomimetic hydrogel here presents a promising approach for effective UC therapy in the clinics.
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