Outcomes after out-of-hospital cardiac arrest have improved over the past 20 years; however, the benefits of some methods used to treat these patients remain uncertain. In particular, the body temperature to be targeted during the first 72 hours of care after an out-of-hospital cardiac arrest remains unclear despite multiple high-quality randomized trials having been conducted to investigate the issue.1-5 Early trials of therapeutic hypothermia targeted a body temperature of 32° to 34°C for 12 hours1 or 24 hours2 but without a specific target temperature in the control group. Subsequently, the Target Temperature Management 33°C versus 36°C after Out-of-Hospital Cardiac Arrest . . .