化学
硫酚
卡宾
催化作用
组合化学
二硫键
反应条件
抗菌剂
有机化学
生物化学
作者
Qifei Wu,Shuquan Wu,Juan Zou,Qingyun Wang,Chengli Mou,Pengcheng Zheng,Yonggui Robin
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-05-18
卷期号:25 (21): 3967-3971
被引量:1
标识
DOI:10.1021/acs.orglett.3c01414
摘要
Substrates containing disulfide bonds, which are more stable and less smelling, could be used as thiophenol precursors in organic synthesis. Herein, an N-heterocyclic carbene (NHC)-catalyzed reaction between α-bromoenals and 2,2'-dithiodibenzaldehydes was developed. Through the sustained release strategy, the side reaction can be effectively inhibited, and the chiral thiochromene derivatives can be obtained with good yields and high optical purities. Application studies showed encouraging results when the desired products were explored for antimicrobial utilities in pesticide development.
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