[Research progress on clinical and mechanisms of chronic pruritus with anxiety and depression].

Chronic pruritus seriously affects the quality of life of patients, which is closely related to stress, anxiety and depression. Prolonged and repeated pruritus can induce negative emotions such as anxiety and depression, while continued increased negative emotions can also promote exacerbation of pruritus, which drives the itch scratch cycle, thereby further aggravating skin damage. More and more studies have explored the mechanism of pruritus, anxiety and depression. This article mainly reviews the clinical relationship between pruritus and anxiety, depression and the new progress of its possible mechanism, providing reference for the prevention, control and effective treatment of chronic pruritus, anxiety and depression.慢性瘙痒严重影响患者生活质量，其与压力、焦虑、抑郁密切相关。长期反复的瘙痒可诱导产生焦虑、抑郁等负面情绪，而持续增加的负面情绪亦会促使瘙痒加剧，推动瘙痒-焦虑循环的产生，从而进一步加重皮肤损伤。目前越来越多的研究对瘙痒与焦虑、抑郁的机制进行了探索，本文主要阐述瘙痒与焦虑、抑郁的临床关系及其可能机制的新进展，为慢性瘙痒及焦虑、抑郁的预防控制及有效治疗提供参考。.