Synthesis of mono-fluorinated heterocycles with a ring-junction nitrogen atom via Rh(iii)-catalyzed CF3-carbenoid C–H functionalization and defluorinative annulation

A Rh-catalyzed two-fold C–F bond cleavage enabled [4 + 2] annulation reaction via CF 3 -carbenoid C–H functionalization of arenes with indoles or various classes of azoles as the directing groups was developed.