免疫系统
免疫疗法
免疫调节
生物
免疫学
计算机科学
神经科学
机制(生物学)
计算生物学
生物信息学
物理
量子力学
作者
Coralie M. Backlund,Sasan Jalili‐Firoozinezhad,Byungji Kim,Darrell J. Irvine
出处
期刊:Annual Review of Immunology
[Annual Reviews]
日期:2023-04-26
卷期号:41 (1): 153-179
被引量:4
标识
DOI:10.1146/annurev-immunol-101721-040259
摘要
Modulation of the immune system is an important therapeutic strategy in a wide range of diseases, and is fundamental to the development of vaccines. However, optimally safe and effective immunotherapy requires precision in the delivery of stimulatory cues to the right cells at the right place and time, to avoid toxic overstimulation in healthy tissues or incorrect programming of the immune response. To this end, biomaterials are being developed to control the location, dose, and timing of vaccines and immunotherapies. Here we discuss fundamental concepts of how biomaterials are used to enhance immune modulation, and evidence from preclinical and clinical studies of how biomaterials-mediated immune engineering can impact the development of new therapeutics. We focus on immunological mechanisms of action and in vivo modulation of the immune system, and we also discuss challenges to be overcome to speed translation of these technologies to the clinic.
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