Squamous cell carcinoma arising from lichen planus

In the present case, we described a middle-aged female presented with a 1-year history of a thick-crusted plaque on an erythematous base of the left heel. 20 years earlier, the patient was diagnosed and treated with lichen planus, leaving residual erythema on the heel. Over the past year, she noticed a progressive enlargement and desquamation of the erythema with a newly formed brown-yellow, hyperkeratotic, and thick-crusted plaque in the center, which was recalcitrant to empirical topical glucocorticoid, antibiotics, and antifungals. Based on the clinical and typical histological findings, a diagnosis of squamous cell carcinoma arising from lichen planus was made.