The risk of death according to left ventricular ejection fraction and right ventricular dilatation in 17 321 adults with heart failure from 40 high‐, middle‐ and low‐income countries – A Global Congestive Heart Failure (G‐CHF) study

医学 心力衰竭 射血分数 心脏病学 内科学
作者
Darryl P. Leong,Philip Joseph,Hisham Dokainish,Stefan Störk,John J.V. McMurray,Lisa Mielniczuk,Sanjib Kumar Sharma,Andrés Orlandini,Kamilu M. Karaye,Antoni Bayés‐Genís,Tara McCready,Alex Grinvalds,Kumar Balasubramanian,Kelley R. Branch,Kristian Kragholm,Salim Yusuf
出处
期刊:European Journal of Heart Failure [Elsevier BV]
标识
DOI:10.1002/ejhf.3550
摘要

Abstract Aims The aim of this study was to describe the prognostic importance of left ventricular ejection fraction (LVEF) versus right ventricular (RV) dilatation and dysfunction in patients with heart failure (HF) from countries of different income levels. Methods and results We enrolled 17 321 participants with HF from 40 countries. Participants were followed for a median (25th–75th percentile) of 2.1 (2.0–4.6) years. Cox proportional hazards models were performed with adjustment for age, sex, HF aetiology, diabetes, atrial fibrillation, chronic obstructive pulmonary disease, tobacco and alcohol use, functional class, and the use of HF medications, blood pressure, serum creatinine and HF duration. During follow‐up, 5738 (33%) participants died and 3569 (21%) were hospitalized for HF. Compared with LVEF ≥50%, the hazard ratios (HR) for death were 0.88 (95% confidence interval [CI] 0.80–0.97, p = 0.009) in patients with LVEF 40–49%, 0.96 (95% CI 0.88–1.05, p = 0.40) for LVEF 30–39%, and 1.18 (95% CI 1.08–1.29, p < 0.0001) for LVEF <30%. RV enlargement was associated with an increased risk of death (HR 1.35, 95% CI 1.26–1.44, p < 0.0001). The relationship between LVEF and death differed according to HF aetiology (interaction p = 0.0010). In ischaemic HF and idiopathic dilated cardiomyopathy, there was a continuous inverse association between LVEF and the risk of death, but in hypertensive, valvular and other HF types, there was no association between LVEF and the risk of mortality. Conclusion Reduced LVEF was associated with worse prognosis in ischaemic and idiopathic dilated cardiomyopathy but not in HF of other causes. RV enlargement was associated with a more marked increase in the risk of death.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
huangqian完成签到,获得积分10
1秒前
1秒前
老毛完成签到,获得积分10
1秒前
1秒前
aaa完成签到,获得积分10
2秒前
tyy发布了新的文献求助10
2秒前
小智完成签到,获得积分10
2秒前
SYX完成签到,获得积分10
2秒前
lz完成签到,获得积分10
3秒前
3秒前
错过的风景完成签到,获得积分10
3秒前
852应助o30采纳,获得10
3秒前
天很蓝完成签到,获得积分10
4秒前
SYLH应助虚拟的皮卡丘采纳,获得10
4秒前
陶醉的妙竹完成签到 ,获得积分10
5秒前
5秒前
奶油布丁发布了新的文献求助10
5秒前
RONG发布了新的文献求助10
5秒前
李健的小迷弟应助zcj采纳,获得10
5秒前
6秒前
6秒前
NexusExplorer应助老王采纳,获得10
6秒前
6秒前
6秒前
无花果应助stern采纳,获得10
6秒前
bkagyin应助十一玮采纳,获得10
7秒前
001发布了新的文献求助10
7秒前
车大花完成签到,获得积分20
7秒前
FFF发布了新的文献求助10
7秒前
研友_kng1r8完成签到,获得积分10
8秒前
8秒前
ll发布了新的文献求助10
8秒前
9秒前
哭泣的凡英完成签到,获得积分20
9秒前
9秒前
闪闪可乐发布了新的文献求助10
9秒前
10秒前
lwtsy发布了新的文献求助10
10秒前
shiko完成签到,获得积分10
10秒前
W~舞发布了新的文献求助10
10秒前
高分求助中
A new approach to the extrapolation of accelerated life test data 1000
Cognitive Neuroscience: The Biology of the Mind 1000
Technical Brochure TB 814: LPIT applications in HV gas insulated switchgear 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Picture Books with Same-sex Parented Families: Unintentional Censorship 500
不知道标题是什么 500
A Preliminary Study on Correlation Between Independent Components of Facial Thermal Images and Subjective Assessment of Chronic Stress 500
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3969398
求助须知:如何正确求助?哪些是违规求助? 3514239
关于积分的说明 11173064
捐赠科研通 3249531
什么是DOI,文献DOI怎么找? 1794934
邀请新用户注册赠送积分活动 875501
科研通“疑难数据库(出版商)”最低求助积分说明 804827