染色质
生物
基因组
支架/基质附着区域
染色体构象捕获
基因组组织
进化生物学
计算生物学
二价染色质
嘉雅宠物
基因
染色质重塑
遗传学
串扰
转录因子
物理
光学
增强子
作者
Lucía Álvarez-González,Aurora Ruiz‐Herrera
标识
DOI:10.1146/annurev-animal-111523-102233
摘要
Studies examining the evolution of genomes have focused mainly on sequence conservation. However, the inner working of a cell implies tightly regulated crosstalk between complex gene networks controlled by small dispersed regulatory elements of physically contacting DNA regions. How these different levels of chromatin organization crosstalk in different species underpins the potential for genome evolutionary plasticity. We review the evolution of chromatin organization across the Animal Tree of Life. We introduce general aspects of the mode and tempo of genome evolution to later explore the multiple layers of genome organization. We argue that both genome and chromosome size modulate patterns of chromatin folding and that chromatin interactions facilitate the formation of lineage-specific chromosomal reorganizations, especially in germ cells. Overall, analyzing the mechanistic forces involved in the maintenance of chromatin structure and function of the germ line is critical for understanding genome evolution, maintenance, and inheritance.
科研通智能强力驱动
Strongly Powered by AbleSci AI