球体
材料科学
微流控
干细胞
细胞外基质
纳米技术
生物医学工程
新生血管
血管生成
细胞
组织工程
伤口愈合
活力测定
细胞生物学
细胞培养
癌症研究
生物
医学
免疫学
生物化学
遗传学
作者
Xiangyi Wu,Danqing Huang,Ye Xu,Guopu Chen,Yuanjin Zhao
标识
DOI:10.1002/adma.202301064
摘要
Abstract Wound dressing patches based on stem cells have demonstrated promising potential in the treatment of diabetic wounds, while their capabilities in the maintenance of cell stemness, effective exchange of cellular substance, and precise targeting of the stem cells remain to be promoted. Here, a novel stem cell spheroid loaded microneedle (MN@SPs) patch is presented using microfluidic templating technology. By leveraging the precise fluid manipulation capabilities of the microfluidic template, stem cell spheroids (SPs) with uniform size can be generated in situ. The resulting SPs exhibit advanced viability and cell functions, as evidenced by the overexpressed genes related to extracellular matrix organization and angiogenesis. By loading these SPs into the microneedles (MNs), the platform enables the precise delivery and exchange of multiple active substances, which contribute to advanced neovascularization, collagen deposition, and tissue reconstruction of diabetic wounds. Overall, this microfluidic‐engineered stem cell therapy platform demonstrates significant promise in promoting wound healing.
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