前额叶皮质
神经科学
心理学
感觉系统
认知
自闭症
自闭症谱系障碍
丘脑
基底神经节
感觉加工
辅助电机区
认知心理学
功能磁共振成像
发展心理学
中枢神经系统
作者
Gerry Leisman,Robert Melillo,Ty Melillo
标识
DOI:10.1016/j.brainresbull.2023.04.004
摘要
The prefrontal cortex is included in a neuronal system that includes the basal ganglia, the thalamus, and the cerebellum. Most of the higher and more complex motor, cognitive, and emotional behavioral functions are thought to be found primarily in the frontal lobes. Insufficient connectivity between the medial prefrontal cortex (mPFC) and other regions of the brain that are distant from each other involved in top-down information processing rely on the global integration of data from multiple input sources and enhance low level perception processes (bottom-up information processing). The reduced deactivation in mPFC and in the rest of the Default Network during global task processing is consistent with the integrative modulatory role served by the mPFC. We stress the importance of understanding the degree to which sensory and movement anomalies in individuals with autism spectrum disorder (ASD) can contribute to social impairment. Further investigation on the neurobiological basis of sensory symptoms and its relationship to other clinical features found in ASD is required Treatment perhaps should not be first behaviorally based but rather based on facilitating sensory motor development.
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