Continuously changing memories: a framework for proactive and non-linear consolidation

The traditional view of long-term memory is that memory traces mature in a predetermined 'linear' process: their neural substrate shifts from rapidly plastic medial temporal regions towards stable neocortical networks. We propose that memories remain malleable, not by repeated reinstantiations of this linear process but instead via dynamic routes of proactive and non-linear consolidation: memories change, their trajectory is flexible and reversible, and their physical basis develops continuously according to anticipated demands. Studies demonstrating memory updating, increasing hippocampal dependence to support adaptive use, and rapid neocortical plasticity provide evidence for continued non-linear consolidation. Although anticipated demand can affect all stages of memory formation, the extent to which it shapes the physical memory trace repeatedly and proactively will require further dedicated research.