光热治疗
材料科学
光学
激光器
过热(电)
等离子纳米粒子
胶体金
纳米颗粒
等离子体子
光热效应
光电子学
纳米技术
物理
量子力学
作者
Mohanna Etemadi,Saeed Golmohammadi,Abolfazl Akbarzadeh,Seyed Hossein Rasta
出处
期刊:Applied Optics
[The Optical Society]
日期:2023-01-17
卷期号:62 (3): 764-764
被引量:3
摘要
Photothermal therapy using nanoparticles is a prominent technique for cancer treatment. The principle is to maximize the heat conversion efficiency using plasmonic nanoparticle-light interaction. Due to their unique optical characteristics derived from their anisotropic structure, gold nanostars (GNSs) have gotten significant attention in photothermal therapy. To design a proper cancer treatment, it is vital to study the thermal effect induced close to the gold nanoparticles, in the vicinity, and the cancerous tissue. A temperature-dependent 2D model based on finite element method models is commonly used to simulate near-IR tumor ablation. The bioheat equation describes the photothermal effect within the GNSs and the environment. Surface cooling and heating strategies, such as the periodical heating method and a reduced laser irradiation area, were investigated to address surface overheating problems. We also determined that the optimal laser radius depends on tumor aspect ratio and laser intensity. Our results provide guidelines to evaluate a safe and feasible temperature range, treatment time, optimal laser intensity, and laser radius to annihilate a tumor volume.
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