亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整地填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

HIV Epidemiology, Care, and Treatment Outcomes Among Student and Nonstudent Youths Living With HIV in Southwest China Between 1996 and 2019: Historical Cohort Study

流行病学 队列研究 医学 队列 环境卫生 多元分析 人口学 老年学 社会学 内科学
作者
Na Wang,Guanghua Lan,Qingqing Zhu,Huanhuan Chen,Jinghua Huang,Qin Meng,Zhiyong Shen,Shanshan Liang,Xiuling Wu,Ling Luo,Rongyi Ye,Jinli Chen,Shengkui Tan,Hui Xing,Yiming Shao,Yuhua Ruan,Mei Lin
出处
期刊:JMIR public health and surveillance [JMIR Publications]
卷期号:9: e38881-e38881
标识
DOI:10.2196/38881
摘要

Background Nearly one-third of new HIV infections occurred among youth in 2019 worldwide. Previous studies suggested that student youths living with HIV and nonstudent youths living with HIV might differ in some risk factors, transmission routes, HIV care, and disease outcomes. Objective This study aimed to compare the HIV epidemic, disease outcomes, and access to care among student and nonstudent youths living with HIV aged 16 to 25 years in Guangxi, China. Methods We performed a historical cohort study by extracting data on all HIV or AIDS cases aged 16 to 25 years in Guangxi, China, during 1996-2019 from the Chinese Comprehensive Response Information Management System of HIV or AIDS. We conducted analyses to assess possible differences in demographic and behavioral characteristics, HIV care, and disease outcomes between student and nonstudent youths living with HIV. Multivariate Cox regression was used to assess differences in mortality and virologic failure between student and nonstudent cases. Results A total of 13,839 youths aged 16 to 25 years were infected with HIV during 1996-2019. Among them, 10,202 cases were infected through sexual contact, most of whom were men (n=5507, 54%); 868 (8.5%) were students, and 9334 (91.5%) were not students. The number of student youths living with HIV was lower before 2006 but gradually increased from 2007 to 2019. In contrast, the nonstudent cases increased rapidly in 2005, then gradually declined after 2012. Student cases were mainly infected through homosexual contact (n=614, 70.7% vs n=1447, 15.5%; P<.001), while nonstudent cases were more likely to be infected through heterosexual contact (n=7887, 84.5% vs n=254, 29.3%; P<.001). Moreover, nonstudent cases had a significantly lower CD4 count than student cases at the time of HIV diagnosis (332 vs 362 cells/μL; P<.001). Nonstudents also had a delayed antiretroviral therapy (ART) initiation compared to students (93 days vs 22 days; P<.001). Furthermore, the mortality rate of 0.4 and 1.0 deaths per 100 person-years were recorded for student and nonstudent youths with HIV, respectively. Overall, the mortality risk in nonstudent cases was 2.3 times that of student cases (adjusted hazard ratio [AHR] 2.3, 95% CI 1.2-4.2; P=.008). The virologic failure rate was 2.3 and 2.6 per 100 person-years among student and nonstudent youths living with HIV, respectively. Nonstudent cases had double the risk of virologic failure compared to student cases (AHR 1.9, 95% CI 1.3-2.6; P<.001). Conclusions Nonstudent youths living with HIV might face a low CD4 count at the time of HIV diagnosis, delayed ART initiation, and increased risk of death and virologic failure. Thus, HIV prevention and interventions should target youths who dropped out of school early to encourage safe sex and HIV screening, remove barriers to HIV care, and promote early ART initiation to curb the HIV epidemic among youths.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
Orange应助Boren采纳,获得10
11秒前
31秒前
Boren发布了新的文献求助10
35秒前
大个应助Boren采纳,获得10
47秒前
Raunio完成签到,获得积分10
49秒前
Akitten发布了新的文献求助10
1分钟前
完美世界应助lhy采纳,获得10
1分钟前
科研通AI2S应助科研通管家采纳,获得10
1分钟前
1分钟前
1分钟前
1分钟前
Boren发布了新的文献求助10
2分钟前
lhy发布了新的文献求助10
2分钟前
董可以发布了新的文献求助10
2分钟前
风吹而过完成签到 ,获得积分10
2分钟前
乐乐应助董可以采纳,获得10
2分钟前
2分钟前
2分钟前
liufan完成签到 ,获得积分10
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
打打应助科研通管家采纳,获得30
3分钟前
科研通AI2S应助科研通管家采纳,获得10
3分钟前
3分钟前
3分钟前
杪夏二八完成签到 ,获得积分10
4分钟前
souther完成签到,获得积分0
4分钟前
乐乐应助Akitten采纳,获得10
4分钟前
5分钟前
kangkang发布了新的文献求助10
5分钟前
传奇完成签到 ,获得积分10
5分钟前
jyy关闭了jyy文献求助
6分钟前
丘比特应助怕孤单的思雁采纳,获得10
6分钟前
6分钟前
6分钟前
Akitten发布了新的文献求助10
6分钟前
6分钟前
Li完成签到,获得积分10
6分钟前
7分钟前
自然的衫完成签到 ,获得积分10
7分钟前
7分钟前
高分求助中
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
A new approach to the extrapolation of accelerated life test data 1000
ACSM’s Guidelines for Exercise Testing and Prescription, 12th edition 500
Indomethacinのヒトにおける経皮吸収 400
Phylogenetic study of the order Polydesmida (Myriapoda: Diplopoda) 370
基于可调谐半导体激光吸收光谱技术泄漏气体检测系统的研究 350
Robot-supported joining of reinforcement textiles with one-sided sewing heads 320
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 3990332
求助须知:如何正确求助?哪些是违规求助? 3532146
关于积分的说明 11256483
捐赠科研通 3271042
什么是DOI,文献DOI怎么找? 1805207
邀请新用户注册赠送积分活动 882302
科研通“疑难数据库(出版商)”最低求助积分说明 809234