HIV Epidemiology, Care, and Treatment Outcomes Among Student and Nonstudent Youths Living With HIV in Southwest China Between 1996 and 2019: Historical Cohort Study

流行病学 队列研究 医学 队列 环境卫生 多元分析 人口学 老年学 社会学 内科学
作者
Na Wang,Guanghua Lan,Qingqing Zhu,Huanhuan Chen,Jinghua Huang,Qin Meng,Zhiyong Shen,Shanshan Liang,Xiuling Wu,Ling Luo,Rongyi Ye,Jinli Chen,Shengkui Tan,Hui Xing,Yiming Shao,Yuhua Ruan,Mei Lin
出处
期刊:JMIR public health and surveillance [JMIR Publications]
卷期号:9: e38881-e38881
标识
DOI:10.2196/38881
摘要

Background Nearly one-third of new HIV infections occurred among youth in 2019 worldwide. Previous studies suggested that student youths living with HIV and nonstudent youths living with HIV might differ in some risk factors, transmission routes, HIV care, and disease outcomes. Objective This study aimed to compare the HIV epidemic, disease outcomes, and access to care among student and nonstudent youths living with HIV aged 16 to 25 years in Guangxi, China. Methods We performed a historical cohort study by extracting data on all HIV or AIDS cases aged 16 to 25 years in Guangxi, China, during 1996-2019 from the Chinese Comprehensive Response Information Management System of HIV or AIDS. We conducted analyses to assess possible differences in demographic and behavioral characteristics, HIV care, and disease outcomes between student and nonstudent youths living with HIV. Multivariate Cox regression was used to assess differences in mortality and virologic failure between student and nonstudent cases. Results A total of 13,839 youths aged 16 to 25 years were infected with HIV during 1996-2019. Among them, 10,202 cases were infected through sexual contact, most of whom were men (n=5507, 54%); 868 (8.5%) were students, and 9334 (91.5%) were not students. The number of student youths living with HIV was lower before 2006 but gradually increased from 2007 to 2019. In contrast, the nonstudent cases increased rapidly in 2005, then gradually declined after 2012. Student cases were mainly infected through homosexual contact (n=614, 70.7% vs n=1447, 15.5%; P<.001), while nonstudent cases were more likely to be infected through heterosexual contact (n=7887, 84.5% vs n=254, 29.3%; P<.001). Moreover, nonstudent cases had a significantly lower CD4 count than student cases at the time of HIV diagnosis (332 vs 362 cells/μL; P<.001). Nonstudents also had a delayed antiretroviral therapy (ART) initiation compared to students (93 days vs 22 days; P<.001). Furthermore, the mortality rate of 0.4 and 1.0 deaths per 100 person-years were recorded for student and nonstudent youths with HIV, respectively. Overall, the mortality risk in nonstudent cases was 2.3 times that of student cases (adjusted hazard ratio [AHR] 2.3, 95% CI 1.2-4.2; P=.008). The virologic failure rate was 2.3 and 2.6 per 100 person-years among student and nonstudent youths living with HIV, respectively. Nonstudent cases had double the risk of virologic failure compared to student cases (AHR 1.9, 95% CI 1.3-2.6; P<.001). Conclusions Nonstudent youths living with HIV might face a low CD4 count at the time of HIV diagnosis, delayed ART initiation, and increased risk of death and virologic failure. Thus, HIV prevention and interventions should target youths who dropped out of school early to encourage safe sex and HIV screening, remove barriers to HIV care, and promote early ART initiation to curb the HIV epidemic among youths.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
朱成豪发布了新的文献求助10
1秒前
deallyxyz应助科研通管家采纳,获得10
1秒前
科目三应助科研通管家采纳,获得10
1秒前
大个应助科研通管家采纳,获得10
1秒前
比比谁的速度快应助曾珍采纳,获得50
1秒前
1秒前
予修应助科研通管家采纳,获得10
1秒前
搜集达人应助科研通管家采纳,获得10
1秒前
wanci应助科研通管家采纳,获得30
1秒前
1秒前
1秒前
吹雪完成签到,获得积分0
1秒前
美好的尔白完成签到,获得积分10
1秒前
O-M175完成签到,获得积分10
2秒前
Jasper应助hahaha123213123采纳,获得10
2秒前
可爱的函函应助天天向上采纳,获得10
3秒前
陈隆完成签到,获得积分10
7秒前
7秒前
高乾飞完成签到 ,获得积分10
8秒前
河大青椒完成签到,获得积分10
8秒前
丘比特应助动听的秋白采纳,获得10
9秒前
晒黑的雪碧完成签到,获得积分10
10秒前
yao chen完成签到,获得积分10
11秒前
catch完成签到,获得积分10
11秒前
Hrx完成签到,获得积分10
11秒前
哎呀哎呀25完成签到,获得积分10
12秒前
15秒前
Shark完成签到 ,获得积分10
15秒前
我要发财完成签到,获得积分10
16秒前
卡卡罗特完成签到,获得积分10
16秒前
16秒前
天天向上完成签到 ,获得积分10
17秒前
Xinxxx完成签到,获得积分10
17秒前
Echoheart完成签到,获得积分10
17秒前
Hrx发布了新的文献求助10
18秒前
我要发财发布了新的文献求助10
20秒前
WJing发布了新的文献求助10
21秒前
haonanchen完成签到,获得积分10
22秒前
彭于晏应助专注的白柏采纳,获得10
22秒前
99v587完成签到,获得积分10
23秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038368
求助须知:如何正确求助?哪些是违规求助? 3576068
关于积分的说明 11374313
捐赠科研通 3305780
什么是DOI,文献DOI怎么找? 1819322
邀请新用户注册赠送积分活动 892672
科研通“疑难数据库(出版商)”最低求助积分说明 815029