内皮素受体
医学
内皮
药理学
心力衰竭
对抗
内皮功能障碍
临床试验
受体
内科学
作者
Philip Ambery,Peter J. Greasley,Robert Menzies,Lena Brynne,Spoorthy Kulkarni,Jan Oscarsson,Anthony P. Davenport
出处
期刊:Clinical Science
[Portland Press]
日期:2024-06-01
卷期号:138 (11): 687-697
摘要
Abstract Endothelin A and B receptors, together with sodium-glucose cotransporter-2 (SGLT-2) channels are important targets in improving endothelial function and intervention with inhibitors has been the subject of multiple mechanistic and clinical outcome trials over recent years. Notable successes include the treatment of pulmonary hypertension with endothelin receptor antagonists, and the treatment of heart failure and chronic kidney disease with SGLT-2 inhibitors. With distinct and complementary mechanisms, in this review, we explore the logic of combination therapy for a number of diseases which have endothelial dysfunction at their heart.
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