Personalized Piezoresistive Anti‐Scar Orthosis with Precise Pressure Monitoring Function Based on Embedded 3D Printing

Abstract Hyperplastic scars, especially keloids, have posed a significant clinical challenge due to their high recurrence rate. Compression therapy, a cost‐effective treatment, has demonstrated efficacy in reducing scarring and preventing recurrence. However, the compression methods exhibit limitations in adapting to the complex contours and accurately adjusting the treatment pressure, resulting in unsatisfactory treatment effects. In this study, silicone is chosen as the substrate layer ink, while the conductive ink is developed by incorporating nano‐carbon black into the polymer composite. These are printed alternately within the supported gels to construct an integrated orthotic device with precise pressure control capabilities and complex structures. Results demonstrated the printed orthosis displayed excellent mechanical properties, durability and biocompatibility. It can successfully detect various stress changes with short response times. The utilization of finite element analysis aided in the design of personalized orthosis to achieve optimal pressure for scar treatment. Finally, orthosis‐mediated pressure treatment is performed on rat tail scar models. By monitoring resistance value, it can be inferred whether the treatment pressure applied by orthosis fell within an optimal range. Overall, personalized piezoresistive anti‐scar orthoses offer an accurate and effective treatment method for scar. This innovative approach presents a novel strategy in the realm of personalized scar management.