癌症免疫疗法
免疫原性
免疫疗法
信使核糖核酸
癌症研究
癌症
免疫系统
抗原
体内
生物
免疫学
基因
生物技术
遗传学
生物化学
作者
Shen Zhang,Jifeng Yu,Yunyun Liu,Bing Xiong,Fang Yan,Yuli Zhu,Shaoyue Li,Liping Sun,Jing Wang,Yikang Sun,Li Wang,Wenwen Yue,Haohao Yin,Huixiong Xu
标识
DOI:10.1002/advs.202307225
摘要
Abstract Therapeutic mRNA vaccines have become powerful therapeutic tools for severe diseases, including infectious diseases and malignant neoplasms. mRNA vaccines encoding tumor‐associated antigens provide unprecedented hope for many immunotherapies that have hit the bottleneck. However, the application of mRNA vaccines is limited because of biological instability, innate immunogenicity, and ineffective delivery in vivo. This study aims to construct a novel mRNA vaccine delivery nanosystem to successfully co‐deliver a tumor‐associated antigen (TAA) encoded by the Wilms' tumor 1 ( WT1 ) mRNA. In this system, named PSB@Nb 1.33 C/mRNA, photosynthetic bacteria (PSB) efficiently delivers the i MXene‐ WT1 mRNA to the core tumor region using photo‐driven and hypoxia‐driven properties. The excellent photothermal therapeutic (PTT) properties of PSB and 2D i Mxene (Nb 1.33 C) trigger tumor immunogenic cell death, which boosts the release of the WT1 mRNA. The released WT1 mRNA is translated, presenting the TAA and amplifying immune effect in vivo. The designed therapeutic strategy demonstrates an excellent ability to inhibit distant tumors and counteract postsurgical lung metastasis. Thus, this study provides an innovative and effective paradigm for tumor immunotherapy, i.e., photo‐immunogene cancer therapy, and establishes an efficient delivery platform for mRNA vaccines, thereby opening a new path for the wide application of mRNA vaccines.
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