亲爱的研友该休息了!由于当前在线用户较少,发布求助请尽量完整的填写文献信息,科研通机器人24小时在线,伴您度过漫漫科研夜!身体可是革命的本钱,早点休息,好梦!

Novel targeted protein degradation technologies as a therapeutic strategy for neurodegenerative diseases

药店 中国 医学 传统医学 家庭医学 政治学 法学
作者
Changyu Ren,Jiao Liu,Shiyun Pu,Houfeng Zhou,Jinqi Li,Jifa Zhang
出处
期刊:Future Medicinal Chemistry [Newlands Press Ltd]
卷期号:15 (5): 395-397
标识
DOI:10.4155/fmc-2023-0035
摘要

Future Medicinal ChemistryVol. 15, No. 5 EditorialNovel targeted protein degradation technologies as a therapeutic strategy for neurodegenerative diseasesChangyu Ren, Jiao Liu, Shiyun Pu, Houfeng Zhou, Jinqi Li & Jifa ZhangChangyu RenDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, ChinaSearch for more papers by this author, Jiao LiuDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, ChinaSearch for more papers by this author, Shiyun PuDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, ChinaSearch for more papers by this author, Houfeng ZhouDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, ChinaSearch for more papers by this author, Jinqi Li*Author for correspondence: E-mail Address: lijinqi2002@126.comDepartment of Pharmacy, Personalized Drug Therapy Key Laboratory, Sichuan Academy of Medical Sciences & Sichuan Provincial People's Hospital, Chengdu, Sichuan, 610072, ChinaSearch for more papers by this author & Jifa Zhang**Author for correspondence: E-mail Address: zjf298257@163.comDepartment of Pharmacy, Chengdu Fifth People's Hospital, Chengdu, Sichuan, 611130, ChinaJoint Research Institution of Altitude Health, West China Hospital of Sichuan University, Chengdu, Sichuan, 610041, ChinaSearch for more papers by this authorPublished Online:31 Mar 2023https://doi.org/10.4155/fmc-2023-0035AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: neurodegenerative diseasesnovel strategyproteolysis targeting chimerastargeted protein degradationReferences1. Kumar D, Md Ashraf G, Bilgrami AL, Imtaiyaz Hassan M. Emerging therapeutic developments in neurodegenerative diseases: a clinical investigation. Drug Discov. Today. 27(10), 103305 (2022).Crossref, Medline, CAS, Google Scholar2. Soto C, Pritzkow S. Protein misfolding, aggregation, and conformational strains in neurodegenerative diseases. Nat. Neurosci. 21(10), 1332–1340 (2018).Crossref, Medline, CAS, Google Scholar3. Tomoshige S, Ishikawa M. PROTACs and other chemical protein degradation technologies for the treatment of neurodegenerative disorders. Angew. Chem. Int. Ed. 60(7), 3346–3354 (2021).Crossref, Medline, CAS, Google Scholar4. Zalewska T, Pawelec P, Ziabska K, Ziemka-Nalecz M. Sexual dimorphism in neurodegenerative diseases and in brain ischemia. Biomolecules. 13(1), 26 (2022).Crossref, Medline, Google Scholar5. Balestrino R, Schapira AHV. Parkinson disease. Eur. J. Neurol. 27(1), 27–42 (2020).Crossref, Medline, CAS, Google Scholar6. Rana T, Behl T, Sehgal A et al. Exploring the role of autophagy dysfunction in neurodegenerative disorders. Mol. Neurobiol. 58(10), 4886–4905 (2021).Crossref, Medline, CAS, Google Scholar7. Araldi RP, D'Amelio F, Vigerelli H et al. Stem cell-derived exosomes as therapeutic approach for neurodegenerative disorders: from biology to biotechnology. Cells. 9(12), 2663 (2020).Crossref, Medline, CAS, Google Scholar8. Setten RL, Rossi JJ, Han S. The current state and future directions of RNAi-based therapeutics. Nat. Rev. Drug Discov. 18(6), 421–446 (2019).Crossref, Medline, CAS, Google Scholar9. Katti A, Diaz BJ, Caragine CM et al. CRISPR in cancer biology and therapy. Nat. Rev. Cancer. 22(5), 259–279 (2022).Crossref, Medline, CAS, Google Scholar10. Kargbo RB. PROTAC compounds targeting α-synuclein protein for treating neurogenerative disorders: Alzheimer's and Parkinson's diseases. ACS Med. Chem. Lett. 11(6), 1086–1087 (2020).Crossref, Medline, CAS, Google Scholar11. Chu T-T, Gao N, Li Q-Q et al. Specific knockdown of endogenous tau protein by peptide-directed ubiquitin-proteasome degradation. Cell Chem. Biol. 23(4), 453–461 (2016).Crossref, Medline, CAS, Google Scholar12. Fang Y, Wang J, Zhao M et al. Progress and challenges in targeted protein degradation for neurodegenerative disease therapy. J. Med. Chem. 65(17), 11454–11477 (2022).Crossref, Medline, CAS, Google Scholar13. Li H, Dong J, Cai M et al. Protein degradation technology: a strategic paradigm shift in drug discovery. J. Hematol. Oncol. 14(1), 138 (2021).Crossref, Medline, CAS, Google Scholar14. Naito M, Ohoka N, Shibata N. SNIPERs – hijacking IAP activity to induce protein degradation. Drug Discov. Today Technol. 31, 35–42 (2019).Crossref, Medline, Google Scholar15. Hirai K, Yamashita H, Tomoshige S et al. Conversion of a PROTAC mutant Huntingtin degrader into small-molecule hydrophobic tags focusing on drug-like properties. ACS Med. Chem. Lett. 13(3), 396–402 (2022).Crossref, Medline, CAS, Google Scholar16. Takahashi D, Arimoto H. Targeting selective autophagy by AUTAC degraders. Autophagy. 16(4), 765–766 (2020).Crossref, Medline, CAS, Google Scholar17. Ding Y, Fei Y, Lu B. Emerging new concepts of degrader technologies. Trends Pharmacol. Sci. 41(7), 464–474 (2020).Crossref, Medline, CAS, Google Scholar18. Zhang J, Huang Y, Liu W et al. Chaperone-mediated autophagy targeting chimeras (CMATAC) for the degradation of ERα in breast cancer. BIOCELL. 44(4), 591–595 (2020).Crossref, CAS, Google Scholar19. Dey SK, Jaffrey SR. RIBOTACs: small molecules target RNA for degradation. Cell Chem. Biol. 26(8), 1047–1049 (2019).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetails Vol. 15, No. 5 STAY CONNECTED Metrics Downloaded 55 times History Received 5 February 2023 Accepted 7 February 2023 Published online 31 March 2023 Published in print March 2023 Information© 2023 Newlands PressKeywordsneurodegenerative diseasesnovel strategyproteolysis targeting chimerastargeted protein degradationFinancial & competing interests disclosureThe authors thank the Natural Science Foundation of Sichuan (No. 2023NSFSC1695), Health Commission of Sichuan Province (No. 21PJ149) and Xinglin Foundation of Chengdu University of TCM (No. YYZX2021043). The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the article apart from those disclosed.No writing assistance was utilized in the production of this manuscript.PDF download
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI

祝大家在新的一年里科研腾飞
更新
大幅提高文件上传限制,最高150M (2024-4-1)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
DL发布了新的文献求助10
刚刚
科研通AI2S应助DL采纳,获得10
8秒前
科研通AI2S应助科研通管家采纳,获得10
13秒前
香蕉觅云应助科研通管家采纳,获得10
13秒前
科研通AI2S应助科研通管家采纳,获得10
13秒前
13秒前
深情安青应助科研通管家采纳,获得10
13秒前
14秒前
27秒前
丘比特应助ln采纳,获得10
30秒前
1分钟前
Leofar完成签到 ,获得积分10
1分钟前
33应助矢思然采纳,获得10
1分钟前
1分钟前
1分钟前
2分钟前
慕青应助淡淡菠萝采纳,获得10
2分钟前
领导范儿应助科研通管家采纳,获得10
2分钟前
英姑应助科研通管家采纳,获得10
2分钟前
2分钟前
淡淡菠萝发布了新的文献求助10
2分钟前
2分钟前
梨炒栗子发布了新的文献求助10
2分钟前
fdj3121发布了新的文献求助10
2分钟前
2分钟前
LYSnow7完成签到 ,获得积分10
3分钟前
虚心橘子完成签到,获得积分10
3分钟前
科研通AI2S应助123采纳,获得10
3分钟前
梨炒栗子完成签到,获得积分10
3分钟前
fdj3121完成签到,获得积分10
3分钟前
3分钟前
甜美的秋尽完成签到,获得积分10
3分钟前
Stitch完成签到 ,获得积分10
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
搜集达人应助科研通管家采纳,获得10
4分钟前
CodeCraft应助科研通管家采纳,获得10
4分钟前
香蕉觅云应助科研通管家采纳,获得10
4分钟前
4分钟前
科研通AI2S应助科研通管家采纳,获得10
4分钟前
4分钟前
高分求助中
Востребованный временем 2500
The Three Stars Each: The Astrolabes and Related Texts 1500
Les Mantodea de Guyane 800
Mantids of the euro-mediterranean area 700
Field Guide to Insects of South Africa 660
Mantodea of the World: Species Catalog 500
Insecta 2. Blattodea, Mantodea, Isoptera, Grylloblattodea, Phasmatodea, Dermaptera and Embioptera 500
热门求助领域 (近24小时)
化学 医学 生物 材料科学 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 基因 遗传学 物理化学 催化作用 细胞生物学 免疫学 冶金
热门帖子
关注 科研通微信公众号,转发送积分 3397898
求助须知:如何正确求助?哪些是违规求助? 3006923
关于积分的说明 8823431
捐赠科研通 2694262
什么是DOI,文献DOI怎么找? 1475747
科研通“疑难数据库(出版商)”最低求助积分说明 682508
邀请新用户注册赠送积分活动 675940