A mixed-valence biotinylated Cu(i/ii) complex for tumor-targeted chemodynamic therapy accompanied by GSH depletion

A “three in one” project involved atomically precise biotinylated complex, VBio-CuICuII, composed of a hydroxyl radical-producible Cu( i ), a Cu( ii ) moiety as a GSH depletor for augmented CDT, and biotin as a cancer-targeting unit.