子宫腺肌病
医学
临床试验
寄生菌
疾病
临床终点
内科学
重症监护医学
妇科
子宫内膜异位症
作者
Melvin George,Kiran Kumar Rathinam,Justin Jacob Abraham,Kiran S. Harish,Heema Preethy S,Sunita Samal
出处
期刊:Reviews on Recent Clinical Trials
[Bentham Science]
日期:2023-05-01
卷期号:18 (2): 83-91
标识
DOI:10.2174/1574887118666230329104546
摘要
Adenomyosis lacks approved pharmacological treatment even after decades of its identification. We performed this study to review the status of clinical research on adenomyosis for finding an effective drug therapy and to identify the most common endpoints used in adenomyosis trials. A systematic search was performed in the PubMed and Clinicaltrials.gov registries to identify interventional trials for analysis without any time and language restrictions. Our search revealed that barely 15 drugs have been assessed for the management of adenomyosis from 2001 to 2021. Among these, LNG-IUS was found to be the most evaluated drug, followed by dienogest. In these trials, the most commonly assessed endpoints included VAS, NPRS for pain, haemoglobin and PBAC for menstrual bleeding, uterine volume, and serum estradiol. There appears to be a need for developing a comprehensive score that takes into consideration all disease symptoms as well as incorporates some objective elements to evaluate the disease.
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