Acute and long-term toxicity of whole pelvis proton radiation therapy for definitive or adjuvant management of gynecologic cancers

医学 不良事件通用术语标准 毒性 近距离放射治疗 子宫内膜癌 阴道癌 不利影响 急性毒性 放射治疗 宫颈癌 内科学 外科 胃肠病学 泌尿科 癌症
作者
Eva Berlin,Nikhil Yegya‐Raman,E Garver,Taoran Li,Lilie L. Lin,Neil K. Taunk
出处
期刊:Gynecologic Oncology [Elsevier BV]
卷期号:172: 92-97 被引量:1
标识
DOI:10.1016/j.ygyno.2023.03.003
摘要

Objective To characterize long-term toxicity and disease outcomes with whole pelvis (WP) pencil beam scanning proton radiation therapy (PBS PRT) for gynecologic malignancies. Methods We reviewed 23 patients treated from 2013 to 2019 with WP PBS PRT for endometrial, cervical, and vaginal cancer. We report acute and late Grade (G)2+ toxicities, graded by Common Terminology Criteria for Adverse Events, Version 5. Disease outcomes were assessed by Kaplan-Meier method. Results Median age was 59 years. Median follow up was 4.8 years. 12 (52.2%) had uterine cancer, 10 (43.5%) cervical, 1 (4.3%) vaginal. 20 (86.9%) were treated post-hysterectomy. 22 (95.7%) received chemotherapy, 12 concurrently (52.2%). The median PBS PRT dose was 50.4GyRBE (range, 45–62.5). 8 (34.8% had para-aortic/extended fields. 10 (43.5%) received brachytherapy boost. Median follow up was 4.8 years. 5-year actuarial local control was 95.2%, regional control 90.9%, distant control 74.7%, both disease control and progression-free survival 71.2%. Overall survival was 91.3%. In the acute period, 2 patients (8.7%) had G2 genitourinary (GU) toxicity, 6 (26.1%) had gastrointestinal (GI) G2–3 toxicity, 17 (73.9%) had G2–4 hematologic (H) toxicity. In the late period, 3 (13.0%) had G2 GU toxicity, 1 (4.3%) had G2 GI toxicity, 2 (8.7%) had G2–3H toxicity. The mean small bowel V15Gy was 213.4 cc. Mean large bowel V15 Gy was 131.9 cc. Conclusions WP PBS PRT for gynecologic malignancies delivers favorable locoregional control. Rates of GU and GI toxicity are low. Acute hematologic toxicity was most common, which may be related to the large proportion of patients receiving chemotherapy.
最长约 10秒,即可获得该文献文件

科研通智能强力驱动
Strongly Powered by AbleSci AI
更新
PDF的下载单位、IP信息已删除 (2025-6-4)

科研通是完全免费的文献互助平台,具备全网最快的应助速度,最高的求助完成率。 对每一个文献求助,科研通都将尽心尽力,给求助人一个满意的交代。
实时播报
刚刚
zzw完成签到,获得积分10
5秒前
Guochunbao完成签到,获得积分10
6秒前
哈哈哈完成签到 ,获得积分10
8秒前
科研通AI5应助蒋念寒采纳,获得10
8秒前
月亮褪色了完成签到 ,获得积分20
12秒前
萱棚完成签到 ,获得积分10
12秒前
13秒前
Cao完成签到 ,获得积分10
13秒前
ENG完成签到,获得积分10
15秒前
alick完成签到,获得积分10
17秒前
刘刘完成签到,获得积分10
18秒前
Tom完成签到,获得积分10
19秒前
Villanellel发布了新的文献求助10
20秒前
程艳完成签到 ,获得积分10
21秒前
MINGHUI完成签到,获得积分10
22秒前
22秒前
子车半烟完成签到,获得积分10
22秒前
24秒前
淳于安筠完成签到,获得积分10
24秒前
雨晴完成签到,获得积分10
27秒前
jbq发布了新的文献求助10
27秒前
joshar完成签到,获得积分10
27秒前
28秒前
量子星尘发布了新的文献求助10
30秒前
blueblue完成签到,获得积分10
32秒前
落后秋烟完成签到,获得积分10
34秒前
大橙子发布了新的文献求助10
35秒前
LMY完成签到 ,获得积分10
35秒前
Betty完成签到 ,获得积分10
35秒前
NexusExplorer应助jbq采纳,获得10
36秒前
渔渔完成签到 ,获得积分10
36秒前
37秒前
Tangyartie完成签到 ,获得积分10
37秒前
skbkbe完成签到 ,获得积分10
38秒前
陈俊雷完成签到 ,获得积分0
39秒前
阿苗完成签到,获得积分10
40秒前
神勇的天问完成签到 ,获得积分10
41秒前
41秒前
advance完成签到,获得积分10
41秒前
高分求助中
【提示信息,请勿应助】关于scihub 10000
Les Mantodea de Guyane: Insecta, Polyneoptera [The Mantids of French Guiana] 3000
徐淮辽南地区新元古代叠层石及生物地层 3000
The Mother of All Tableaux: Order, Equivalence, and Geometry in the Large-scale Structure of Optimality Theory 3000
Handbook of Industrial Diamonds.Vol2 1100
Global Eyelash Assessment scale (GEA) 1000
Picture Books with Same-sex Parented Families: Unintentional Censorship 550
热门求助领域 (近24小时)
化学 材料科学 医学 生物 工程类 有机化学 生物化学 物理 内科学 纳米技术 计算机科学 化学工程 复合材料 遗传学 基因 物理化学 催化作用 冶金 细胞生物学 免疫学
热门帖子
关注 科研通微信公众号,转发送积分 4038184
求助须知:如何正确求助?哪些是违规求助? 3575908
关于积分的说明 11373872
捐赠科研通 3305715
什么是DOI,文献DOI怎么找? 1819255
邀请新用户注册赠送积分活动 892662
科研通“疑难数据库(出版商)”最低求助积分说明 815022