In this study, a flexible and foldable frequency-reconfigurable antenna of liquid metal with cube structure is proposed. Based on the origami theory, the operating frequency of the antenna can be changed by folding the designed antenna to make it into a cube structure. The designed antenna does not have a rigid connection structure and has two modes: planer and folded modes. The re-flection coefficient of the antenna is 8.51-8.66 GHz (resonated at 8.59 GHz) and 12.54-12.83 GHz (resonated at 12.69 GHz) in the range below -10dB in the planer state and the 90° folded state, respectively. The antenna of this design has the characteristics of omnidirectional radiation, and the peak gain is 6.53 dBi. This work solves the problem of strain caused by traditional rigid materials and provides a liquid metal reconfigurable antenna that can be easily folded and used repeatedly.