肌醇
类固醇生成因子1
内分泌学
内科学
化学
生物
医学
生物化学
受体
转录因子
核受体
基因
作者
A. Wojciechowska,Paulina Zając,Justyna Gogola-Mruk,Magdalena K. Kowalik,Anna Ptak
标识
DOI:10.3390/ijms252010974
摘要
Considering the properties of myo-inositol (MI) and D-chiro-inositol (DCI), which are well known in polycystic ovary syndrome therapy, and the limitations of adult granulosa cell tumor (AGCT) treatment, especially for androgen-secreting tumors, we studied the role of MI and DCI in the androgen-rich environment of AGCTs. For this purpose, we analyzed the mRNA expression of steroidogenic genes and the secretion of progesterone (P4) and 17β-estradiol (E2) in an unstimulated and/or dihydrotestosterone (DHT)-stimulated environment under MI and DCI influence. Thus, we used the HGrC1 and KGN cell lines as in vitro models of healthy and cancerous granulosa cells. We found that DHT, the most potent androgen, increased E2 secretion and steroidogenic acute regulatory protein (
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