Electrical Stimulating Redox Membrane Incorporated with PVA/Gelatin Nanofiber for Diabetic Wound Healing

明胶 伤口愈合 生物相容性 乙烯醇 材料科学 纳米纤维 生物医学工程 血管生成 壳聚糖 慢性伤口 巨噬细胞极化 刺激 纳米技术 化学 体外 医学 外科 复合材料 巨噬细胞 癌症研究 生物化学 聚合物 冶金 内科学
作者
Jeong‐Uk Kim,Junghyeon Ko,Y. J. Kim,Minwoong Jung,Myoung-Hoon Jang,Young‐Hyeon An,Nathaniel S. Hwang
出处
期刊:Advanced Healthcare Materials [Wiley]
标识
DOI:10.1002/adhm.202400170
摘要

Abstract Chronic wounds adversely affect the quality of life. Although electrical stimulation has been utilized to treat chronic wounds, there are still limitations to practicing it due to the complicated power system. Herein, an electrostimulating membrane incorporated with electrospun nanofiber (M‐sheet) to treat diabetic wounds is developed. Through the screen printing method, the various alternate patterns of both Zn and AgCl on a polyurethane substrate, generating redox‐mediated electrical fields are introduced. The antibacterial ability of the patterned membrane against both E. coli and S. aureus is confirmed. Furthermore, the poly(vinyl alcohol) (PVA)/gelatin electrospun fiber is incorporated into the patterned membrane to enhance biocompatibility and maintain the wet condition in the wound environment. The M‐sheet can improve cell proliferation and migration in vitro and has an immune regulatory effect by inducing the polarization of macrophage to the M2 phenotype. Finally, when applied to a diabetic skin wound model, the M‐sheet displays an accelerated wound healing rate and enhances re‐epithelialization, collagen synthesis, and angiogenesis. It suggests that the M‐sheet is a simple and portable system for the spontaneous generation of electrical stimulation and has great potential to be used in the practical wound and other tissue engineering applications.
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