Preferences in treating polyomavirus infection in kidney transplant recipients: A discrete choice experiment with patients, caregivers, and clinicians

医学 多项式logistic回归 肾移植 肾移植 干预(咨询) 感染控制 内科学 逻辑回归 重症监护医学 移植 精神科 机器学习 计算机科学
作者
Chanel H. Chong,Germaine Wong,Eric Au,Nicole Scholes‐Robertson,Shyamsundar Muthuramalingam,Simon D. Roger,Karen Keung,Allison Tong,Armando Teixeira‐Pinto,Martin Howell
出处
期刊:Transplant Infectious Disease [Wiley]
标识
DOI:10.1111/tid.14390
摘要

Abstract Background Treatment strategies for BK polyomavirus (BKPyV) infection in kidney transplant recipients are heterogeneous among clinicians. We aimed to identify the treatment preferences of key stakeholders for BKPyV infection and measure the trade‐offs between treatment outcomes. Methods Adult kidney transplant recipients, caregivers, and clinicians were eligible to participate in a discrete choice experiment between February 2021 and June 2022. The five treatment‐related attributes were achieving viral clearance and optimal graft function, as well as reducing the risk of graft loss, acute rejection, and complications. Results were analyzed using multinomial logistic models. Results In total, 109 participants (57 kidney transplant recipients, 10 caregivers, and 42 health professionals) were included. The most important attribute was the risk of graft loss, followed by side effects and acute rejection. As the risk of graft loss increased, all participants were less inclined to accept an assigned treatment strategy. For instance, if graft loss risk was increased from 1% to 50%, the probability of uptake of a treatment strategy for BKPyV infection was reduced from 87% to 3%. Conclusion Graft loss is the predominant concern for patients, caregivers, and health professionals when deciding on the treatment for BKPyV infection, and should be included in intervention trials of BKPyV infection. image
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