纳米载体
乙醇酸
Zeta电位
分散性
药理学
化学
气溶胶化
粒径
PLGA公司
纳米颗粒
药品
气动直径
药物输送
吸入
治疗指标
纳米技术
材料科学
乳酸
医学
有机化学
气溶胶
麻醉
物理化学
生物
细菌
遗传学
作者
Druva Sarika Rongala,Suyash M. Patil,Nitesh K. Kunda
出处
期刊:Nanomedicine
日期:2024-07-29
卷期号:: 1-13
标识
DOI:10.1080/17435889.2024.2370225
摘要
Background: Development of an inhalable nanoformulation of dacomitinib (DMB) encapsulated in poly-(lactic-co-glycolic acid) nanoparticles (NPs) to improve solubility, facilitate direct lung delivery and overcome the systemic adverse effects. Methods: DMB-loaded poly-(lactic-co-glycolic acid) NPs were prepared using solvent evaporation and characterized for particle size, polydispersity index and zeta-potential. The NPs were evaluated for in vitro drug release, aerosolization performance and in vitro efficacy studies. Results: The NPs showed excellent particle characteristics and displayed a cumulative release of ∼40% in 5 days. The NPs demonstrated a mass median aerodynamic diameter of ∼3 μm and fine particle fraction of ∼80%. Further, in vitro cell culture studies showed improved cytotoxic potential of DMB-loaded NPs compared with free drug. Conclusion: The study underscores the potential of DMB-loaded NPs as a viable approach for non-small cell lung cancer treatment.
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